Figure 1
From: A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway
Structure of the JAK2-STAT5 pathway model proposed. Legend: Epo: concentration of Epo in the extracellular medium; EJ: fraction of non-activated EpoR/JAK2 complex; pEpJ: fraction of activated EpoR/JAK2 complex; S: fraction of non-activated and non-dimerised STAT5 in the cytosol; DpS: fraction of activated and dimerised STAT5 in the cytosol; DpS nc : fraction of activated and dimerised STAT5 inside the nucleus.