Figure 8
From: A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway
Average fraction of dimerised phosphorylated STAT5 in the nucleus ( DpS nc, osc ) (norm. units) during oscillatory stimulation. The simulated data was averaged for several following periods. The behaviour of the system was analysed for oscillatory stimuli with an average period duration T ∈ [0.5, 1440] minutes, and an average concentration of Epo ocs ∈ [10-6, 10] units/ml. In all the simulations, the signal was averaged for 12 periods of the oscillatory stimulus.