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Table 1 Hyperarcs of the logical model

From: Host-pathogen systems biology: logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction

-> c-Met
-> HGF
-> H. pylori
-> PIP2
-> PTEN
ATF2 ->
α-catenin/β-catenin/E-cadherin ->
Calpain ->
c-Myc ->
Elk1 ->
ETS1 ->
NF-κB ->
Talin ->
c-Jun ->
STAT3 ->
01.) HGF· c-Met -> HGF/c-Met
02.) HGF/c-Met -> Gab1
03.) Gab1 -> SHP2
04.) HGF/c-Met -> SHP2
05.) HGF/c-Met -> Grb2
06.) Gab1 -> PI3K
07.) HGF/c-Met -> c-Cbl
08.) c-Cbl -> PI3K
09.) Gab1 -> Crk/CrkL
10.) HGF/c-Met -> Shc1
11.) Shc1 -> Grb2
12.) c-Cbl -> Crk/CrkL
13.) Crk/CrkL -> DOCK180
14.) DOCK180 -> Rac1
15.) RAC1 -> STAT3
16.) HGF/c-Met -> STAT3
17.) PI3K -> ILK
18.) !PTEN· PI3K· PIP2 -> PIP3
19.) PIP3 -> PDK1
20.) PDK1· ILK -> AKT1
21.) AKT1 -> RAC1
22.) AKT1 -> PAK1
23.) Rac1 -> PAK1
24.) Rac1· Calmodulin -> IQGAP-1
25.) PAK1 -> MKK4
26.) MKK4 -> JNK
27.) JNK -> c-JUN
28.) JNK -> ELK1
29.) JNK -> ATF2
30.) PAK1 -> IKK
31.) !IKK -> IκBα
32.) !IκBα -> NF-κB
33.) !SHP2· Gab1 -> RasGAP
34.) Grb2 -> SOS1
35.) !RasGAP· SOS1 -> Ras
36.) Ras -> Raf1
37.) Raf1 -> MEK
38.) MEK -> ERK1/2
39.) ERK1/2 -> ELK1
40.) ERK1/2 -> c-Myc
41.) ERK1/2 -> ETS
42.) Gab1 -> PLCγ1
43.) PLCγ1· PIP2 -> IP3
44.) PLCγ1· PIP2 -> DAG
45.) IP3 -> Ca2+
46.) DAG· Ca2+ -> PKCα
47.) PKCα -> Raf1
48.) Ca2+ -> Calmodulin
49.) !IQGAP-1 -> α-catenin/β-catenin/E-cadherin
50.) c-SRC· FYN· H. pylori -> CagA
51.) !H. pylori -> CSK
52.) CagA -> CSK
53.) !CSK -> c-SRC
54.) !CSK -> FYN
55.) CagA -> Crk/CrkL
56.) CagA -> SHP2
57.) !SHP2 -> FAK
58.) FAK -> PIPKIγ661
59.) PIPKIγ661 -> Talin
60.) FAK· ERK1/2 -> Calpain 2
61.) CagA· c-Met -> CagA/c-Met
62.) CagA/c-Met -> PLCγ1
  1. Exclamation mark denotes a logical NOT and dots within the equation indicate AND operations.
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