Figure 1
From: Exploiting the pathway structure of metabolism to reveal high-order epistasis
Pathway fragments enable a "relaxed" cut set criterion. The feasible ux cone K of a metabolic network is contained inside the cone Kigenerated by the pathway fragment collection E(Ki) obtained from any iteration i of the tableau algorithm. Because of this property, the knockout of a reaction set R that intersects all j-containing pathway fragments in E(Ki) will be guaranteed to "cut" the ux through an objective reaction j.