Figure 2From: Exploiting the pathway structure of metabolism to reveal high-order epistasisNetKO uncovers high-cardinality minimal cut sets. Our network-based genome-scale knockout design approach preferentially discovers high cardinality minimal cut sets for biomass production: 11,218 of the 11,706 minimal cut sets discovered are of cardinality 5 or above. These minimal cut sets represent high-order epistasis between parallelized metabolic network components.Back to article page