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Table 1 Putative direct c-Myc targets: biological processes

From: Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: Identification of the c-myc regulatory gene network

Probe Set ID Gene Symbol Gene Title Biological process
1420821_at Sgpp1 sphingosine-1-phosphate phosphatase 1 apoptosis
1428480_at Cdca8 cell division cycle associated 8 cell cycle
1435306_a_at Kif11 kinesin family member 11 cell cycle
1423903_at Pvr poliovirus receptor cell-cell adhesion
1422889_at Pcdh18 protocadherin 18 cell-cell adhesion
1427489_at Itga8 integrin alpha 8 cell-matrix adhesion
1419717_at Sema3e sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E development
1448595_a_at Bex1 brain expressed gene 1 development
1422198_a_at Shmt1 serine hydroxymethyltransferase 1 (soluble) amino acid metabolism
1418483_a_at Ggta1 glycoprotein galactosyltransferase alpha 1, 3 carbohydrate metabolism
1421879_at Mtmr1 myotubularin related protein 1 lipid metabolism
1426575_at Sgms1 sphingomyelin synthase 1 lipid metabolism
1445103_at Tmem23 Transmembrane protein 23 lipid metabolism
1417300_at Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B lipid metabolism
1421957_a_at Pcyt1a phosphate cytidylyltransferase 1, choline, alpha isoform lipid metabolism
1422702_at Azin1 antizyme inhibitor 1 polyamine metabolism
1417190_at Pbef1 pre-B-cell colony-enhancing factor 1 NAD biosynthetic process
1423088_at Tmod3 tropomodulin 3 negative regulation of cell motility
1420847_a_at Fgfr2 fibroblast growth factor receptor 2 proliferation
1415691_at Dlg1 discs, large homolog 1 (Drosophila) proliferation
1422966_a_at Tfrc transferrin receptor proliferation
1420924_at Timp2 tissue inhibitor of metalloproteinase 2 proliferation
1420020_at Suz12 suppressor of zeste 12 homolog (Drosophila) proliferation
1416657_at Akt1 thymoma viral proto-oncogene 1 proliferation
1420852_a_at B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 protein amino acid glycosylation
1426342_at Stt3b STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) protein amino acid glycosylation
1425581_s_at Galnt7 UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7 protein amino acid glycosylation
1415692_s_at Canx calnexin protein folding
1429502_at Stch stress 70 protein chaperone, microsome-associated, human homolog protein folding
1427074_at Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 protein modification
1426721_s_at Tiparp TCDD-inducible poly(ADP-ribose) polymerase protein modification
1439151_at Msrb3 methionine sulfoxide reductase B3 protein repair
1431361_at Prcp prolylcarboxypeptidase (angiotensinase C) proteolysis
1421857_at Adam17 a disintegrin and metallopeptidase domain 17 proteolysis
1422528_a_at Zfp36l1 zinc finger protein 36, C3H type-like 1 regulation of mRNA stability
1420975_at Baz1b bromodomain adjacent to zinc finger domain, 1B regulation of transcription, DNA-dependent
1421162_a_at Nfia nuclear factor I/A regulation of transcription, DNA-dependent
1423773_at Gpbp1 GC-rich promoter binding protein 1 regulation of transcription, DNA-dependent
1423441_at Tfb2m transcription factor B2, mitochondrial regulation of transcription, DNA-dependent
1422864_at Runx1 runt related transcription factor 1 regulation of transcription, DNA-dependent
1416018_at Dr1 down-regulator of transcription 1 regulation of transcription, DNA-dependent
1418280_at Klf6 Kruppel-like factor 6 regulation of transcription, DNA-dependent
1425465_a_at Senp2 SUMO/sentrin specific peptidase 2 regulation of transcription, DNA-dependent
1421908_a_at Tcf12 transcription factor 12 regulation of transcription, DNA-dependent
1434643_at Tbl1x transducin (beta)-like 1 X-linked regulation of transcription, DNA-dependent
1426531_at Zmynd11 zinc finger, MYND domain containing 11 regulation of transcription, DNA-dependent
1419976_s_at Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 regulation of transcription, DNA-dependent
1432143_a_at Hbp1 high mobility group box transcription factor 1 regulation of transcription, DNA-dependent
1427418_a_at Hif1a hypoxia inducible factor 1, alpha subunit regulation of transcription, DNA-dependent
1421835_at Mtap7 microtubule-associated protein 7 response to osmotic stress
1415996_at Txnip thioredoxin interacting protein response to oxidative stress
1416467_at Ddx3x DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked RNA helicase activity
1415807_s_at Sfrs2 splicing factor, arginine/serine-rich 2 (SC-35) RNA splicing
1425625_at Il13ra1 interleukin 13 receptor, alpha 1 signal transduction
1426892_at Utrn utrophin signal transduction
1433706_a_at Ptplad1 protein tyrosine phosphatase-like A domain containing 1 signal transduction
1424947_at Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 signal transduction
1425538_x_at Ceacam1 CEA-related cell adhesion molecule 1 signal transduction
1420918_at Sgk3 serum/glucocorticoid regulated kinase 3 signal transduction
1437295_at Pkn2 protein kinase N2 signal transduction
1416504_at Ulk1 Unc-51 like kinase 1 (C. elegans) signal transduction
1418489_a_at Calcrl calcitonin receptor-like signal transduction
1421239_at Il6st interleukin 6 signal transducer signal transduction
1420814_at Gdi2 guanosine diphosphate (GDP) dissociation inhibitor 2 signal transduction
1420696_at Sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C signal transduction
1418022_at Narg1 NMDA receptor-regulated gene 1 transcription
1420307_a_at Pitpnb phosphatidylinositol transfer protein, beta transport
1419970_at Slc35a5 solute carrier family 35, member A5 transport carbohydrate
1421839_at Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 transport cholesterol
1417622_at Slc12a2 solute carrier family 12, member 2 transport ion
1418257_at Slc12a7 solute carrier family 12, member 7 transport ion
1416832_at Slc39a8 solute carrier family 39 (metal ion transporter), member 8 transport metal ion
1426712_at Slc6a15 solute carrier family 6 (neurotransmitter transporter), member 15 transport neurotransmitter
1421641_at Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 transport neurotransmitter
1421167_at Atp11a ATPase, class VI, type 11A transport phospholipid
1423597_at Atp8a1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 transport phospholipid
1428065_at Slc44a2 solute carrier family 44, member 2 transport protein
1416375_at Ap3m1 adaptor-related protein complex 3, mu 1 subunit transport protein
1436508_at 2410014A08Rik RIKEN cDNA 2410014A08 gene transport protein
1416189_a_at Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) transport protein
1426775_s_at Scamp1 secretory carrier membrane protein 1 transport protein
1420867_at Tmed2 transmembrane emp24 domain trafficking protein 2 transport protein
1421955_a_at Nedd4 neural precursor cell expressed, developmentally down-regulted gene 4 ubiquitin cycle
1416680_at Ube3a ubiquitin protein ligase E3A ubiquitin cycle
1426495_at 2410042D21Rik RIKEN cDNA 2410042D21 gene ?
1419152_at 2810417H13Rik RIKEN cDNA 2810417H13 gene ?
1421603_a_at Ceacam2 CEA-related cell adhesion molecule 2 ?
1417821_at D17H6S56E-5 DNA segment, Chr 17, human D6S56E 5 ?
1423557_at Ifngr2 interferon gamma receptor 2 ?
1421064_at Mpp5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) ?
1421814_at Msn moesin ?
1423479_at Nol11 nucleolar protein 11 ?
1426806_at Obfc2a oligonucleotide/oligosaccharide-binding fold containing 2A ?
1424778_at Reep3 receptor accessory protein 3 ?
  1. The table gives the 94 genes which are putatively directly regulated by c-Myc and the corresponding biological processes they are involved in. In this table, the 15 targets stored already in the Myc Target Database are marked bold.
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