Table 1 Putative direct c-Myc targets: biological processes

1420821_at

Sgpp1

sphingosine-1-phosphate phosphatase 1

apoptosis

1428480_at

Cdca8

cell division cycle associated 8

cell cycle

1435306_a_at

Kif11

kinesin family member 11

cell cycle

1423903_at

Pvr

poliovirus receptor

cell-cell adhesion

1422889_at

Pcdh18

protocadherin 18

cell-cell adhesion

1427489_at

Itga8

integrin alpha 8

cell-matrix adhesion

1419717_at

Sema3e

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

development

1448595_a_at

Bex1

brain expressed gene 1

development

1422198_a_at

Shmt1

serine hydroxymethyltransferase 1 (soluble)

amino acid metabolism

1418483_a_at

Ggta1

glycoprotein galactosyltransferase alpha 1, 3

carbohydrate metabolism

1421879_at

Mtmr1

myotubularin related protein 1

lipid metabolism

1426575_at

Sgms1

sphingomyelin synthase 1

lipid metabolism

1445103_at

Tmem23

Transmembrane protein 23

lipid metabolism

1417300_at

Smpdl3b

sphingomyelin phosphodiesterase, acid-like 3B

lipid metabolism

1421957_a_at

Pcyt1a

phosphate cytidylyltransferase 1, choline, alpha isoform

lipid metabolism

1422702_at

Azin1

antizyme inhibitor 1

polyamine metabolism

1417190_at

Pbef1

pre-B-cell colony-enhancing factor 1

NAD biosynthetic process

1423088_at

Tmod3

tropomodulin 3

negative regulation of cell motility

1420847_a_at

Fgfr2

fibroblast growth factor receptor 2

proliferation

1415691_at

Dlg1

discs, large homolog 1 (Drosophila)

proliferation

1422966_a_at

Tfrc

transferrin receptor

proliferation

1420924_at

Timp2

tissue inhibitor of metalloproteinase 2

proliferation

1420020_at

Suz12

suppressor of zeste 12 homolog (Drosophila)

proliferation

1416657_at

Akt1

thymoma viral proto-oncogene 1

proliferation

1420852_a_at

B3gnt2

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

protein amino acid glycosylation

1426342_at

Stt3b

STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)

protein amino acid glycosylation

1425581_s_at

Galnt7

UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7

protein amino acid glycosylation

1415692_s_at

Canx

calnexin

protein folding

1429502_at

Stch

stress 70 protein chaperone, microsome-associated, human homolog

protein folding

1427074_at

Pcmtd2

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

protein modification

1426721_s_at

Tiparp

TCDD-inducible poly(ADP-ribose) polymerase

protein modification

1439151_at

Msrb3

methionine sulfoxide reductase B3

protein repair

1431361_at

Prcp

prolylcarboxypeptidase (angiotensinase C)

proteolysis

1421857_at

Adam17

a disintegrin and metallopeptidase domain 17

proteolysis

1422528_a_at

Zfp36l1

zinc finger protein 36, C3H type-like 1

regulation of mRNA stability

1420975_at

Baz1b

bromodomain adjacent to zinc finger domain, 1B

regulation of transcription, DNA-dependent

1421162_a_at

Nfia

nuclear factor I/A

regulation of transcription, DNA-dependent

1423773_at

Gpbp1

GC-rich promoter binding protein 1

regulation of transcription, DNA-dependent

1423441_at

Tfb2m

transcription factor B2, mitochondrial

regulation of transcription, DNA-dependent

1422864_at

Runx1

runt related transcription factor 1

regulation of transcription, DNA-dependent

1416018_at

Dr1

down-regulator of transcription 1

regulation of transcription, DNA-dependent

1418280_at

Klf6

Kruppel-like factor 6

regulation of transcription, DNA-dependent

1425465_a_at

Senp2

SUMO/sentrin specific peptidase 2

regulation of transcription, DNA-dependent

1421908_a_at

Tcf12

transcription factor 12

regulation of transcription, DNA-dependent

1434643_at

Tbl1x

transducin (beta)-like 1 X-linked

regulation of transcription, DNA-dependent

1426531_at

Zmynd11

zinc finger, MYND domain containing 11

regulation of transcription, DNA-dependent

1419976_s_at

Nfatc3

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

regulation of transcription, DNA-dependent

1432143_a_at

Hbp1

high mobility group box transcription factor 1

regulation of transcription, DNA-dependent

1427418_a_at

Hif1a

hypoxia inducible factor 1, alpha subunit

regulation of transcription, DNA-dependent

1421835_at

Mtap7

microtubule-associated protein 7

response to osmotic stress

1415996_at

Txnip

thioredoxin interacting protein

response to oxidative stress

1416467_at

Ddx3x

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked

RNA helicase activity

1415807_s_at

Sfrs2

splicing factor, arginine/serine-rich 2 (SC-35)

RNA splicing

1425625_at

Il13ra1

interleukin 13 receptor, alpha 1

signal transduction

1426892_at

Utrn

utrophin

signal transduction

1433706_a_at

Ptplad1

protein tyrosine phosphatase-like A domain containing 1

signal transduction

1424947_at

Dync1li1

dynein cytoplasmic 1 light intermediate chain 1

signal transduction

1425538_x_at

Ceacam1

CEA-related cell adhesion molecule 1

signal transduction

1420918_at

Sgk3

serum/glucocorticoid regulated kinase 3

signal transduction

1437295_at

Pkn2

protein kinase N2

signal transduction

1416504_at

Ulk1

Unc-51 like kinase 1 (C. elegans)

signal transduction

1418489_a_at

Calcrl

calcitonin receptor-like

signal transduction

1421239_at

Il6st

interleukin 6 signal transducer

signal transduction

1420814_at

Gdi2

guanosine diphosphate (GDP) dissociation inhibitor 2

signal transduction

1420696_at

Sema3c

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

signal transduction

1418022_at

Narg1

NMDA receptor-regulated gene 1

transcription

1420307_a_at

Pitpnb

phosphatidylinositol transfer protein, beta

transport

1419970_at

Slc35a5

solute carrier family 35, member A5

transport carbohydrate

1421839_at

Abca1

ATP-binding cassette, sub-family A (ABC1), member 1

transport cholesterol

1417622_at

Slc12a2

solute carrier family 12, member 2

transport ion

1418257_at

Slc12a7

solute carrier family 12, member 7

transport ion

1416832_at

Slc39a8

solute carrier family 39 (metal ion transporter), member 8

transport metal ion

1426712_at

Slc6a15

solute carrier family 6 (neurotransmitter transporter), member 15

transport neurotransmitter

1421641_at

Slc6a2

solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

transport neurotransmitter

1421167_at

Atp11a

ATPase, class VI, type 11A

transport phospholipid

1423597_at

Atp8a1

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

transport phospholipid

1428065_at

Slc44a2

solute carrier family 44, member 2

transport protein

1416375_at

Ap3m1

adaptor-related protein complex 3, mu 1 subunit

transport protein

1436508_at

2410014A08Rik

RIKEN cDNA 2410014A08 gene

transport protein

1416189_a_at

Sec61a1

Sec61 alpha 1 subunit (S. cerevisiae)

transport protein

1426775_s_at

Scamp1

secretory carrier membrane protein 1

transport protein

1420867_at

Tmed2

transmembrane emp24 domain trafficking protein 2

transport protein

1421955_a_at

Nedd4

neural precursor cell expressed, developmentally down-regulted gene 4

ubiquitin cycle

1416680_at

Ube3a

ubiquitin protein ligase E3A

ubiquitin cycle

1426495_at

2410042D21Rik

RIKEN cDNA 2410042D21 gene

?

1419152_at

2810417H13Rik

RIKEN cDNA 2810417H13 gene

?

1421603_a_at

Ceacam2

CEA-related cell adhesion molecule 2

?

1417821_at

D17H6S56E-5

DNA segment, Chr 17, human D6S56E 5

?

1423557_at

Ifngr2

interferon gamma receptor 2

?

1421064_at

Mpp5

membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

?

1421814_at

Msn

moesin

?

1423479_at

Nol11

nucleolar protein 11

?

1426806_at

Obfc2a

oligonucleotide/oligosaccharide-binding fold containing 2A

?

1424778_at

Reep3

receptor accessory protein 3

?