Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: Identification of the c-myc regulatory gene network

Table 3 Analysis of flanking sequences (+/- 100 bp) around the 110 c-Myc binding sites

Matrix	Hits in sequences (205 bp) of induced promoters	Hits in sequences (205 bp) of control promoters	Fold-Occurrence	P-Wert
V$MYC_Q2	96	7	13.71	1.04731E-98
V$MYCMAX_01	16	4	4.00	2.00649E-06
V$MYCMAX_02	10	1	10.00	7.25446E-08
V$MYCMAX_B	18	2	9.00	1.73837E-12
V$MAX_01	34	6	5.67	4.50618E-17
V$EBOX_Q6_01	25	2	12.50	2.36615E-20
V$E2F_Q2	50	21	2.38	2.08371E-10
V$E2F1_Q3	22	7	3.14	1.12327E-06
V$E2F1_Q3_01	11	3	3.67	0.000171353
V$E2F1_Q6	11	5	2.20	0.007294131
V$AP2_Q6	17	7	2.43	0.000392586
V$AP2_Q6_01	14	5	2.80	0.000339388
V$AP2ALPHA_03	30	8	3.75	1.41269E-10
V$AP2GAMMA_01	21	2	10.50	1.04239E-15
V$ZF5_B	85	37	2.30	7.71777E-21
V$ZIC3_01	22	10	2.20	0.000213134

The TRANSFAC identifier of the respective matrix, the number of hits in the 110 different sequences (205 bp) of induced gene promoters, the number of hits in the 110 different sequences (205 bp) of control (non-regulated) gene promoters, and the corresponding fold occurrences are given in this table. The occurrence value of the respective binding site in the promoters of control genes is set to 1. Significance of the representation value of binding sites in flanking sequences (+/- 100 bp) around the 110 c-Myc binding sites in the promoters of induced genes is measured by the p-value derived from the binomial distribution.

ISSN: 1752-0509