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Table 4 Analysis of promoters of induced genes – without any c-Myc binding sites and without any binding sites of TFs which were induced by c-Myc – with respect to binding sites of other TFs

From: Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: Identification of the c-myc regulatory gene network

Matrix

Number of binding sites in promoters of 96 induced genes

Number of binding sites in promoters of 100 non-regulated genes

Fold occurrence

Significance (p-value)

V$HNF4_01

6

1

6.25

0.000375206

V$CREL_01

10

2

5.21

2.03259E-05

V$NFKAPPAB65_01

5

1

5.21

0.002449147

V$NFKB_Q6_01

5

1

5.21

0.002449147

V$PPARG_01

11

4

2.86

0.001151136

V$NFKB_C

5

2

2.6

0.031112513

V$P53_DECAMER_Q2

10

4

2.6

0.003533721

V$COUPTF_Q6

12

5

2.5

0.002051505

V$ELF1_Q6

12

5

2.5

0.002051505

V$IRF_Q6_01

26

11

2.46

7.01224E-06

V$P53_02

7

3

2.43

0.017329258

V$NF1_Q6

18

8

2.34

0.000369053

V$PPAR_DR1_Q2

11

5

2.29

0.005502861

V$CEBPGAMMA_Q6

19

9

2.2

0.000532298

V$AP1_Q4

10

5

2.08

0.013373232

V$NF1_Q6_01

10

5

2.08

0.013373232

V$E2F1DP2_01

8

4

2.08

0.023927388

V$E2F4DP2_01

8

4

2.08

0.023927388

V$AP1_Q2

11

6

1.91

0.016631957

V$AR_01

11

6

1.91

0.016631957

V$OCT1_03

36

21

1.79

9.18715E-05

V$HIC1_03

12

7

1.79

0.019471252

V$HNF4_01_B

12

7

1.79

0.019471252

V$PLZF_02

47

28

1.75

6.68834E-06

V$ETS_Q6

20

12

1.74

0.005001828

V$FREAC4_01

10

6

1.74

0.033328378

V$XFD1_01

10

6

1.74

0.033328378

V$OCT1_06

13

8

1.69

0.021905095

V$ETS_Q4

22

14

1.64

0.006219504

V$CAAT_01

14

9

1.62

0.023973145

V$CDPCR1_01

12

8

1.56

0.038985854

V$E47_02

18

12

1.56

0.017018836

V$P53_01

6

4

1.56

0.096354785

V$STAT_Q6

12

8

1.56

0.038985854

V$MZF1_02

37

25

1.54

0.001169513

V$PPARG_02

79

64

1.52

0.001699828

V$HMGIY_Q3

46

32

1.5

0.000431589

  1. The TRANSFAC identifier of the respective matrix, the number of hits in the 96 induced gene promoters, the number of hits in the 100 non-regulated control gene promoters, and the corresponding fold occurrences are given in this table. The occurrence value of the respective binding site in the promoters of control genes is set to 1. Significance of the representation value of TF binding sites in the promoters is measured by the p-value derived from the binomial distribution.