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Table 4 Analysis of promoters of induced genes – without any c-Myc binding sites and without any binding sites of TFs which were induced by c-Myc – with respect to binding sites of other TFs

From: Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: Identification of the c-myc regulatory gene network

Matrix Number of binding sites in promoters of 96 induced genes Number of binding sites in promoters of 100 non-regulated genes Fold occurrence Significance (p-value)
V$HNF4_01 6 1 6.25 0.000375206
V$CREL_01 10 2 5.21 2.03259E-05
V$NFKAPPAB65_01 5 1 5.21 0.002449147
V$NFKB_Q6_01 5 1 5.21 0.002449147
V$PPARG_01 11 4 2.86 0.001151136
V$NFKB_C 5 2 2.6 0.031112513
V$P53_DECAMER_Q2 10 4 2.6 0.003533721
V$COUPTF_Q6 12 5 2.5 0.002051505
V$ELF1_Q6 12 5 2.5 0.002051505
V$IRF_Q6_01 26 11 2.46 7.01224E-06
V$P53_02 7 3 2.43 0.017329258
V$NF1_Q6 18 8 2.34 0.000369053
V$PPAR_DR1_Q2 11 5 2.29 0.005502861
V$CEBPGAMMA_Q6 19 9 2.2 0.000532298
V$AP1_Q4 10 5 2.08 0.013373232
V$NF1_Q6_01 10 5 2.08 0.013373232
V$E2F1DP2_01 8 4 2.08 0.023927388
V$E2F4DP2_01 8 4 2.08 0.023927388
V$AP1_Q2 11 6 1.91 0.016631957
V$AR_01 11 6 1.91 0.016631957
V$OCT1_03 36 21 1.79 9.18715E-05
V$HIC1_03 12 7 1.79 0.019471252
V$HNF4_01_B 12 7 1.79 0.019471252
V$PLZF_02 47 28 1.75 6.68834E-06
V$ETS_Q6 20 12 1.74 0.005001828
V$FREAC4_01 10 6 1.74 0.033328378
V$XFD1_01 10 6 1.74 0.033328378
V$OCT1_06 13 8 1.69 0.021905095
V$ETS_Q4 22 14 1.64 0.006219504
V$CAAT_01 14 9 1.62 0.023973145
V$CDPCR1_01 12 8 1.56 0.038985854
V$E47_02 18 12 1.56 0.017018836
V$P53_01 6 4 1.56 0.096354785
V$STAT_Q6 12 8 1.56 0.038985854
V$MZF1_02 37 25 1.54 0.001169513
V$PPARG_02 79 64 1.52 0.001699828
V$HMGIY_Q3 46 32 1.5 0.000431589
  1. The TRANSFAC identifier of the respective matrix, the number of hits in the 96 induced gene promoters, the number of hits in the 100 non-regulated control gene promoters, and the corresponding fold occurrences are given in this table. The occurrence value of the respective binding site in the promoters of control genes is set to 1. Significance of the representation value of TF binding sites in the promoters is measured by the p-value derived from the binomial distribution.