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Figure 1 | BMC Systems Biology

Figure 1

From: Can single knockouts accurately single out gene functions?

Figure 1

How many synthetic lethals are there?. For each perturbation size (knockout depth) we plot: -- the frequency of lethal gene interactions, left axis; and -- the absolute number of lethal interactions, right axis. For sizes 1,2 we use the true numbers, while 3,4 are based on 2 · 106 samples each (about 10% and 0.1% of the total interactions space, respectively). For all sizes we only count lethal gene groups for which no subgroup is in itself lethal. Compare with -- for experimentally derived frequencies [5,10] for 1D and 2D interactions.

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