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Table 1 Results of single vs. multiple perturbations analysis.

From: Can single knockouts accurately single out gene functions?

  As revealed by single knockouts As revealed by multiple knockouts
(a) System size 131 215
(b) Cumulative CV of essential genes 96% 94.8%
(c) Mean relative error 45%
(d) Number of essential genes 101
  1. (a) Number of genes implicated as involved in the task. In the multiple case, we only count genes with a statistically significant CV (corrected for multiple testing by FDR [37]: the expected proportion of falsely counted genes is controlled at 10%, or 22 in this case); (b) Total contribution of the essential genes; (c) Mean relative error of CVs; M R E = 1 | I | i I | γ i ( 1 ) γ i ( n ) γ i ( n ) | MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaemyta0KaemOuaiLaemyrauKaeyypa0tcfa4aaSaaaeaacqaIXaqmaeaadaabdaqaaiabdMeajbGaay5bSlaawIa7aaaakiabgwSixpaaqababaWaaqWaaKqbagaadaWcaaqaaiabeo7aNnaaDaaabaGaemyAaKgabaGaeiikaGIaeGymaeJaeiykaKcaaiabgkHiTiabeo7aNnaaDaaabaGaemyAaKgabaGaeiikaGIaemOBa4MaeiykaKcaaaqaaiabeo7aNnaaDaaabaGaemyAaKgabaGaeiikaGIaemOBa4MaeiykaKcaaaaaaOGaay5bSlaawIa7aaWcbaGaemyAaKMaeyicI4SaemysaKeabeqdcqGHris5aaaa@552D@ averaging only for the involved genes I; (d) Number of essential genes.