Table 3 The top 50 effect terms of reactions with "pathway step" and "molecular interaction" type in the TRANSPATH database.
From: Systematic reconstruction of TRANSPATH data into Cell System Markup Language
No. | Effect | Rule | #(%) | No. | Effect | Rule | #(%) |
|---|---|---|---|---|---|---|---|
1 | binding | 1-1 | 28411 (29.5%) | 26 | sumoylation | 1-1 | 89486 (92.8%) |
2 | expression | 5-1 | 53378 (55.4%) | 27 | decrease of phosphorylation | 3-1 | 89846 (93.2%) |
3 | DNA binding | 4-1 | 59299 (61.5%) | 28 | dephosphorylation | 1-1 | 90183 (93.5%) |
4 | phosphorylation | 1-1 | 64800 (67.2%) | 29 | increase of binding | 2-1 | 90516 (93.9%) |
5 | activation | 2-1 | 68829 (71.4%) | 30 | predicted | 7 | 90844 (94.2%) |
6 | increase of abundance | 2-1 | 72516 (75.2%) | 31 | binding; phosphorylation | 1–2 | 91130 (94.5%) |
7 | DNA binding; transactivation | 4-1 | 75753 (78.6%) | 32 | translocation | 1-1 | 91397 (94.8%) |
8 | decrease of abundance | 3-1 | 77255 (80.1%) | 33 | acetylation | 1-1 | 91629 (95%) |
9 | increase of phosphorylation | 2-1 | 78570 (81.5%) | 34 | binding; oligomerization | 1–2 | 91853 (95.3%) |
10 | regulation of abundance | 6-2 | 79728 (82.7%) | 35 | transrepression | 2–3 | 92052 (95.5%) |
11 | inhibition | 3–4 | 80790 (83.8%) | 36 | regulation of phosphorylation | 2–4 | 92247 (95.7%) |
12 | regulation of activity | 6-1 | 81810 (84.9%) | 37 | decrease of secretion | 3-1 | 92425 (95.9%) |
13 | regulation of localization | 2–4 | 82806 (85.9%) | 38 | activation; binding | 3-2 | 92585 (96%) |
14 | transactivation | 2-1 | 83507 (86.6%) | 39 | automodification; phosphorylation | 1-1 | 92734 (96.2%) |
15 | DNA binding; transregulation | 4-3 | 84120 (87.3%) | 40 | degradation | 1-1 | 92866 (96.3%) |
16 | increase of secretion | 2-1 | 84721 (87.9%) | 41 | exchange | 1-1 | 92995 (96.5%) |
17 | regulation of protein activity | 6-1 | 85280 (88.5%) | 42 | oligomerization | 1-1 | 93114 (96.6%) |
18 | DNA binding; transrepression | 4-2 | 85814 (89%) | 43 | decrease of protein stability | 3-3 | 93226 (96.7%) |
19 | cleavage | 1-1 | 86327 (89.5%) | 44 | hydrolysis | 1-1 | 93327 (96.8%) |
20 | activation; increase of phosphorylation | 2-2 | 86836 (90.1%) | 45 | dissociation; phosphorylation | 1–3 | 93420 (96.9%) |
21 | activation; expression | 5-2 | 87309 (90.6%) | 46 | degradation; destabilization | 3-3 | 93510 (97%) |
22 | ubiquitination | 1-1 | 87766 (91%) | 47 | regulation of secretion | 6-2 | 93593 (97.1%) |
23 | binding; regulation of localization | 1–2 | 88216 (91.5%) | 48 | activation; increase of abundance | 2-2 | 93673 (97.2%) |
24 | processing | 1-1 | 88665 (92%) | 49 | increase of processing | 2-1 | 93753 (97.3%) |
25 | binding; regulation of protein activity | 1–2 | 89094 (92.4%) | 50 | decrease of binding | 3-1 | 93832 (97.3%) |