Figure 1

Global protein-protein interactions of apoptosis in cancerous and normal cells. (A) Apoptotic protein-protein interaction network in HeLa cells, showing 183 nodes and 552 edges. (B) Apoptotic protein-protein interaction network in normal primary lung fibroblasts, showing 175 nodes and 547 edges. Each interaction was calculated twice and only interactions with two '1' scores after AIC evaluation was considered 'true' interactions (see Supplementary Table 1 for detailed information). All protein-protein interaction networks in this study were constructed with Osprey version 1.2.0.