Figure 5
Graphical representation of individual protein interactions and cooperative protein interactions. Our dynamic protein interaction equation includes three individual or binary protein-protein interactions to the target protein x [t] (protein x1 [t], x2 [t], and x3 [t]) and one cooperative interaction between protein x1 [t] and x2 [t] to the target protein x [t]. a denotes the influence of a target protein at one time point to the target protein at the next time point; b i denotes individual or binary interaction of protein i with target protein x [t]; and c ij denotes the cooperative interaction ability of protein i and protein j on the target protein x.