Figure 5
From: Incorporation of enzyme concentrations into FBA and identification of optimal metabolic pathways
Core carbon metabolic network. A simplified core carbon metabolic network [15]. The network consists of 12 metabolites and 23 reactions. The stoichiometry of the metabolic reactions are described as follows [15]: R1 : A + ATP → B; R2a: B → 2ATP + 2NADH + C; R2b: C + 2ATP + 2NADH → B; R3 : B → F ; R4 :C → G; R5a: G → 0.8C + 2NADH; R5b: G → 0.8C + 2NADH; R6 : C → 2ATP + 3D; R7 : C + 4NADH → 3E; R8a: G + ATP + 2NADH → H; R8b: H → G + ATP + 2NADH; R res :NADH + O2 → ATP; C → Biomass; F → Biomass; H → Biomass; 10ATP → Biomass. The stoichiometry of the transport processes are described as follows: Tc 1: Carbon 1 → A; Tc 2: Carbon 2 → A; T f : Fext → F; T d : D → Dext; T e : E → Eext; T h : Hext → H; To 2: Oxygen → O 2. The biomass flux R z is as follows: C + F + H + 10ATP → 1 Biomass is indicated by white arrows.