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Figure 5 | BMC Systems Biology

Figure 5

From: Incorporation of enzyme concentrations into FBA and identification of optimal metabolic pathways

Figure 5

Core carbon metabolic network. A simplified core carbon metabolic network [15]. The network consists of 12 metabolites and 23 reactions. The stoichiometry of the metabolic reactions are described as follows [15]: R1 : A + ATPB; R2a: B → 2ATP + 2NADH + C; R2b: C + 2ATP + 2NADH → B; R3 : BF ; R4 :CG; R5a: G → 0.8C + 2NADH; R5b: G → 0.8C + 2NADH; R6 : C → 2ATP + 3D; R7 : C + 4NADH → 3E; R8a: G + ATP + 2NADHH; R8b: HG + ATP + 2NADH; R res :NADH + O2ATP; CBiomass; FBiomass; HBiomass; 10ATPBiomass. The stoichiometry of the transport processes are described as follows: Tc 1: Carbon 1 → A; Tc 2: Carbon 2 → A; T f : FextF; T d : DDext; T e : EEext; T h : HextH; To 2: OxygenO 2. The biomass flux R z is as follows: C + F + H + 10ATP → 1 Biomass is indicated by white arrows.

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