Figure 1

Examples of St-GIs. (A) Enrichment of structural similarity within GIs of two query genes, MSI1 and BAR-1. For each p-value (X-axis), plotted are the percentages of structurally similar proteins and of St-GIs with the query (Y-axis). (B) A multiple alignment of 4 protein domain structures: SCOP:87716 (red), SCOP:27660 (green), SCOP:107666 (blue), and SCOP:86078 (violet). These domains are involved in 3 GIs of the MSI1 query gene with genes HIR1, HIR2 and CTF4, respectively. The core of the alignment forms a beta-propeller (yellow). (C) An alignment of two protein domain structures: SCOP:19114 (red) and SCOP:19216 (green). The former domain is assigned to genes BAR-1 and HMP-2, while the latter is assigned to HGRS-1. The BAR-1 gene is known to interact with the two other genes. The core of the alignment forms a superhelix (yellow).