Figure 5

Regulatory module implicated in the control of lipid metabolism genes associated to iIN800 Reporter Metabolites, which were determined by comparing N-limited and C-limited growth. Without the expanded model iIN800, the importance of cellular regulation stemming from lipid metabolism would be missed. High scoring Reporter Metabolites (diamonds), metabolic genes associated to Reporter Metabolites (circles), and genes encoding regulators (triangles). The blue, red, gray and green edges represent metabolite-gene interactions from the genome-scale metabolic model, protein-DNA interactions from ChIP-CHIP data, protein-DNA interactions from YPD and protein-protein interactions from BioGRID, respectively.