Constructing disease-specific gene networks using pair-wise relevance metric: Application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements

Table 2 The gene interactions that involved 3 known cancer genes in colon cancer-specific gene network

Hub gene	Gene	AFV	p	Hub gene	Gene	AFV	p
IL8	EPHB4	9.53	0.0001	DES	MORF4L2	10.23	0.0001
	RBM9	9.46	0.0001		RPL30	8.37	0.0001
	ENO1	7.54	0.0001		RBM9	4.38	0.0002
	EIF2S2	5.88	0.0001		TPT1	4.03	0.0002
	IL1R2	4.34	0.0002		PRPS1	3.69	0.0002
	MAOB	3.98	0.0002		IL8	3.69	0.0002
	F13A1	3.72	0.0002		CD37	3.59	0.0002
	DES	3.69	0.0002		MYH9	3.53	0.0002
	TPM1	3.64	0.0002		PLAUR	2.17	0.0007
	RPL30	3.45	0.0002		KIF5A	1.71	0.0008
	NK4	3.41	0.0002		SRF	1.58	0.0011
	PRPS1	2.88	0.0002		IFITM2	1.53	0.0011
	ACTB	2.59	0.0003		RPS9:15*	1.22	0.0023
	FGFR2	2.52	0.0003		RPS9:275*	0.87	0.0036
	HLA-B	2.06	0.0007		ENO1	0.83	0.0039
	FUT1	1.92	0.0008		HNRPD	0.83	0.0039
	TNNC1	1.35	0.0016		PHKG2	0.82	0.0041
	RPS29	1.33	0.0018		ACTA1	0.70	0.0051
	RPLP1	1.29	0.0019
	EEF1G	1.24	0.0023	ENO1	IL8	7.54	0.0001
	RPL37	1.15	0.0024		F13A1	2.69	0.0003
	CANX	1.07	0.0026		RBM9	1.21	0.0023
	OPHN1	1.06	0.0026		RPS29	1.00	0.0032
	ATF4	0.97	0.0033		DES	0.83	0.0039
	MT1G	0.93	0.0036		AP3B2	0.79	0.0045
	A2M	0.86	0.0037		EPHB4	0.76	0.0046
	NFIA	0.84	0.0037		MAOB	0.72	0.0048
	ZFP36L1	0.73	0.0047		TPM1	0.72	0.0050
	SRF	0.72	0.0048		EPHB3	0.65	0.0064
	PRTN3	0.71	0.0050		ACTB	0.61	0.0074
	UBTF	0.67	0.0060		EIF2S2	0.61	0.0074
	CPSF1	0.65	0.0064		MYL9	0.58	0.0081
	TMSB4X	0.54	0.0098		FUT1	0.56	0.0090

ISSN: 1752-0509