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Table 2 The gene interactions that involved 3 known cancer genes in colon cancer-specific gene network

From: Constructing disease-specific gene networks using pair-wise relevance metric: Application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements

Hub gene Gene AFV p Hub gene Gene AFV p
IL8 EPHB4 9.53 0.0001 DES MORF4L2 10.23 0.0001
  RBM9 9.46 0.0001   RPL30 8.37 0.0001
  ENO1 7.54 0.0001   RBM9 4.38 0.0002
  EIF2S2 5.88 0.0001   TPT1 4.03 0.0002
  IL1R2 4.34 0.0002   PRPS1 3.69 0.0002
  MAOB 3.98 0.0002   IL8 3.69 0.0002
  F13A1 3.72 0.0002   CD37 3.59 0.0002
  DES 3.69 0.0002   MYH9 3.53 0.0002
  TPM1 3.64 0.0002   PLAUR 2.17 0.0007
  RPL30 3.45 0.0002   KIF5A 1.71 0.0008
  NK4 3.41 0.0002   SRF 1.58 0.0011
  PRPS1 2.88 0.0002   IFITM2 1.53 0.0011
  ACTB 2.59 0.0003   RPS9:15* 1.22 0.0023
  FGFR2 2.52 0.0003   RPS9:275* 0.87 0.0036
  HLA-B 2.06 0.0007   ENO1 0.83 0.0039
  FUT1 1.92 0.0008   HNRPD 0.83 0.0039
  TNNC1 1.35 0.0016   PHKG2 0.82 0.0041
  RPS29 1.33 0.0018   ACTA1 0.70 0.0051
  RPLP1 1.29 0.0019     
  EEF1G 1.24 0.0023 ENO1 IL8 7.54 0.0001
  RPL37 1.15 0.0024   F13A1 2.69 0.0003
  CANX 1.07 0.0026   RBM9 1.21 0.0023
  OPHN1 1.06 0.0026   RPS29 1.00 0.0032
  ATF4 0.97 0.0033   DES 0.83 0.0039
  MT1G 0.93 0.0036   AP3B2 0.79 0.0045
  A2M 0.86 0.0037   EPHB4 0.76 0.0046
  NFIA 0.84 0.0037   MAOB 0.72 0.0048
  ZFP36L1 0.73 0.0047   TPM1 0.72 0.0050
  SRF 0.72 0.0048   EPHB3 0.65 0.0064
  PRTN3 0.71 0.0050   ACTB 0.61 0.0074
  UBTF 0.67 0.0060   EIF2S2 0.61 0.0074
  CPSF1 0.65 0.0064   MYL9 0.58 0.0081
  TMSB4X 0.54 0.0098   FUT1 0.56 0.0090
  1. *the two probes correspond to the same gene RPS9
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BMC Systems Biology

ISSN: 1752-0509

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