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Table 1 Geometric parameters for the healthy tissue (human vastus lateralis muscle)

From: A compartment model of VEGF distribution in blood, healthy and diseased tissues

Skeletal muscle characteristic Value Unit Reference
Muscle fibers    
Cross sectional area of one fiber 3000 μ m2 [6]
Perimeter of one fiber 222 μ m [6]
Capillary-fiber ratio 1.38   [37]
Capillary density 420 capillaries/mm2 tissue [6]
Muscle fiber density 304 fibers/mm2 tissue [6]
Volume fractions    
Interstitial space 8.16% cm3/cm3 tissue [38, 39]
Fibers 89.98% cm3/cm3 tissue [6]
Microvessels 1.86% cm3/cm3 tissue [6]
   of which vascular space 1.4% cm3/cm3 tissue [40]
Microvessels    
Internal diameter of microvessel 6.56 μ m [6]
Thickness of endothelial cell 0.5 μ m [41]
External diameter of microvessel 7.56 μ m [6]
Cross sectional area of one microvessel 45 μ m2 [6]
Perimeter of one microvessel 26 μ m [6]
Surface areas    
Muscle fibers 664 cm2/cm3 tissue [6]
Microvessels 108 cm2/cm3 tissue [6]
Basement membranes (BM)    
Thickness of muscle fiber BM 24 nm [42]
Basement membrane volume (muscle fiber) 0.00159 cm3/cm3 tissue Calculated
   of which available to VEGF 0.000307 cm3/cm3 tissue Calculated
Thickness of microvessel BM 43 nm [42]
Basement membrane volume (microvessel) 0.00045 cm3/cm3 tissue Calculated
   of which available to VEGF 0.000087 cm3/cm3 tissue Calculated
Extracellular matrix volume 0.07951 cm3/cm3 tissue Calculated
   of which available to VEGF 0.061987 cm3/cm3 tissue Calculated
Skeletal muscle nuclear domain (SMND) surface area 1850 μ m2 [6]
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