A compartment model of VEGF distribution in blood, healthy and diseased tissues

BMC Systems Biology

Table 1 Geometric parameters for the healthy tissue (human vastus lateralis muscle)

Skeletal muscle characteristic	Value	Unit	Reference
*Muscle fibers*
Cross sectional area of one fiber	3000	μ m²	[6]
Perimeter of one fiber	222	μ m	[6]
*Capillary-fiber ratio*	1.38		[37]
*Capillary density*	420	capillaries/mm² tissue	[6]
*Muscle fiber density*	304	fibers/mm² tissue	[6]
*Volume fractions*
Interstitial space	8.16%	cm³/cm³ tissue	[38, 39]
Fibers	89.98%	cm³/cm³ tissue	[6]
Microvessels	1.86%	cm³/cm³ tissue	[6]
of which vascular space	1.4%	cm³/cm³ tissue	[40]
*Microvessels*
Internal diameter of microvessel	6.56	μ m	[6]
Thickness of endothelial cell	0.5	μ m	[41]
External diameter of microvessel	7.56	μ m	[6]
Cross sectional area of one microvessel	45	μ m²	[6]
Perimeter of one microvessel	26	μ m	[6]
*Surface areas*
Muscle fibers	664	cm²/cm³ tissue	[6]
Microvessels	108	cm²/cm³ tissue	[6]
*Basement membranes (BM)*
Thickness of muscle fiber BM	24	nm	[42]
Basement membrane volume (muscle fiber)	0.00159	cm³/cm³ tissue	Calculated
of which available to VEGF	0.000307	cm³/cm³ tissue	Calculated
Thickness of microvessel BM	43	nm	[42]
Basement membrane volume (microvessel)	0.00045	cm³/cm³ tissue	Calculated
of which available to VEGF	0.000087	cm³/cm³ tissue	Calculated
Extracellular matrix volume	0.07951	cm³/cm³ tissue	Calculated
of which available to VEGF	0.061987	cm³/cm³ tissue	Calculated
*Skeletal muscle nuclear domain (SMND) surface area*	1850	μ m²	[6]

ISSN: 1752-0509