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Table 2 Kinetic parameters of VEGF in the healthy tissue (human vastus lateralis muscle)

From: A compartment model of VEGF distribution in blood, healthy and diseased tissues

  Measured parameters Tissue parameters
  Value Unit Value Unit
VEGF binding to VEGFR1
kon 3 107 M-1 s-1 4.8 10-1 (pmol/cm3 tissue)-1 s-1
koff 10-3 s-1   
Kd 33 pM 2.0 10-3 pmol/cm3 tissue
VEGF binding to VEGFR2
kon 107 M-1 s-1 1.6 10-1 (pmol/cm3 tissue)-1 s-1
koff 10-3 s-1   
Kd 100 pM 6.4 10-3 pmol/cm3 tissue
VEGF165 binding to NRP1
kon 3.2 106 M-1 s-1 5.1 10-2 (pmol/cm3 tissue)-1 s-1
koff 10-3 s-1   
Kd 312 pM 2.0 10-2 pmol/cm3 tissue
VEGF165 binding to GAGs
kon 4.2 105 M-1 s-1 6.7 10-3 (pmol/cm3 tissue)-1 s-1
koff 10-2 s-1   
Kd 24 nM 1.5 pmol/cm3 tissue
Coupling of NRP1 & VEGFR2
kcV165R2, N1 3.1 1013 (mol/cm2)-1 s-1 2.8 10-1 (pmol/cm3 tissue)-1 s-1
koffV165R2,N1 10-3 s-1   
kcV165N1,R2 1014 (mol/cm2)-1 s-1 9.2 10-1 (pmol/cm3 tissue)-1 s-1
koffV165N1,R2 10-3 s-1   
VEGFR1 coupling to NRP1
kcR1,N1 1014 (mol/cm2)-1 s-1 9.2 10-1 (pmol/cm3 tissue)-1 s-1
kdissocR1,N 10-2 s-1   
VEGFR internalization
kint,R 2.8 10-4 s-1   
kint,C 2.8 10-4 s-1   
  1. The derivation of these parameters is found in [6]. In this table, 6.24 107 (pmol/cm3 tissue)/M and 1.09 1014 (pmol/cm3 tissue)/(mol/cm2 EC). Here, M = moles/liter available interstitial fluid volume.
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