A compartment model of VEGF distribution in blood, healthy and diseased tissues

BMC Systems Biology

Table 4 Geometric parameters for the breast tumor

	Value	Unit	Reference
*Cancer cells*
Tumor cells external diameter	17	μ m	[43]
Volume of one cell	2572	μ m³	[4]
Surface area of one cell	997	μ m²	[4]
*Microvessels*
Average luminal diameter	10.3	μ m	[44, 45]
Endothelial cell thickness	0.5	μ m	[4]
Average external diameter	11.3	μ m	[4]
Cross sectional area of one vessel	100.3	μ m²	[4]
Perimeter of one vessel	43.7	μ m	[4]
*Volume fractions*
Interstitial space	61.1%	cm³/cm³ tissue	[46, 47]
Cancer cells	37%	cm³/cm³ tissue	[4]
Microvessels	2.4%	cm³/cm³ tissue	[4]
of which intravascular space	2%		[4]
*Surface areas*
Tumor cells	1416	cm²/cm³ tissue	[4]
Microvessels	105	cm²/cm³ tissue	[4]
*Basement membranes (BM)*
Thickness of tumor cell BM	30	nm	[4]
Basement membrane volume (tumor cells)	0.00388	cm³/cm³ tissue	Calculated
of which available to VEGF	0.002446	cm³/cm³ tissue	Calculated
Thickness of microvessel BM	50	nm	[4]
Basement membrane volume (microvessels)	0.00043	cm³/cm³ tissue	Calculated
of which available to VEGF	0.000270	cm³/cm³ tissue	Calculated
Extracellular matrix volume	0.6062	cm³/cm³ tissue	Calculated
of which available to VEGF	0.519308	cm³/cm³ tissue	Calculated

ISSN: 1752-0509