From: A compartment model of VEGF distribution in blood, healthy and diseased tissues
Value | Unit | Reference | |
---|---|---|---|
Cancer cells | |||
Tumor cells external diameter | 17 | μ m | [43] |
Volume of one cell | 2572 | μ m3 | [4] |
Surface area of one cell | 997 | μ m2 | [4] |
Microvessels | |||
Average luminal diameter | 10.3 | μ m | [44, 45] |
Endothelial cell thickness | 0.5 | μ m | [4] |
Average external diameter | 11.3 | μ m | [4] |
Cross sectional area of one vessel | 100.3 | μ m2 | [4] |
Perimeter of one vessel | 43.7 | μ m | [4] |
Volume fractions | |||
Interstitial space | 61.1% | cm3/cm3 tissue | [46, 47] |
Cancer cells | 37% | cm3/cm3 tissue | [4] |
Microvessels | 2.4% | cm3/cm3 tissue | [4] |
of which intravascular space | 2% | [4] | |
Surface areas | |||
Tumor cells | 1416 | cm2/cm3 tissue | [4] |
Microvessels | 105 | cm2/cm3 tissue | [4] |
Basement membranes (BM) | |||
Thickness of tumor cell BM | 30 | nm | [4] |
Basement membrane volume (tumor cells) | 0.00388 | cm3/cm3 tissue | Calculated |
of which available to VEGF | 0.002446 | cm3/cm3 tissue | Calculated |
Thickness of microvessel BM | 50 | nm | [4] |
Basement membrane volume (microvessels) | 0.00043 | cm3/cm3 tissue | Calculated |
of which available to VEGF | 0.000270 | cm3/cm3 tissue | Calculated |
Extracellular matrix volume | 0.6062 | cm3/cm3 tissue | Calculated |
of which available to VEGF | 0.519308 | cm3/cm3 tissue | Calculated |