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Table 4 Geometric parameters for the breast tumor

From: A compartment model of VEGF distribution in blood, healthy and diseased tissues

  Value Unit Reference
Cancer cells    
Tumor cells external diameter 17 μ m [43]
Volume of one cell 2572 μ m3 [4]
Surface area of one cell 997 μ m2 [4]
Microvessels    
Average luminal diameter 10.3 μ m [44, 45]
Endothelial cell thickness 0.5 μ m [4]
Average external diameter 11.3 μ m [4]
Cross sectional area of one vessel 100.3 μ m2 [4]
Perimeter of one vessel 43.7 μ m [4]
Volume fractions    
Interstitial space 61.1% cm3/cm3 tissue [46, 47]
Cancer cells 37% cm3/cm3 tissue [4]
Microvessels 2.4% cm3/cm3 tissue [4]
   of which intravascular space 2%   [4]
Surface areas    
Tumor cells 1416 cm2/cm3 tissue [4]
Microvessels 105 cm2/cm3 tissue [4]
Basement membranes (BM)    
Thickness of tumor cell BM 30 nm [4]
Basement membrane volume (tumor cells) 0.00388 cm3/cm3 tissue Calculated
   of which available to VEGF 0.002446 cm3/cm3 tissue Calculated
Thickness of microvessel BM 50 nm [4]
Basement membrane volume (microvessels) 0.00043 cm3/cm3 tissue Calculated
   of which available to VEGF 0.000270 cm3/cm3 tissue Calculated
Extracellular matrix volume 0.6062 cm3/cm3 tissue Calculated
   of which available to VEGF 0.519308 cm3/cm3 tissue Calculated
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