Skip to main content

Table 6 VEGF concentration and receptor densities for the tumor (breast cancer)

From: A compartment model of VEGF distribution in blood, healthy and diseased tissues

 

Measured parameter

Tissue model

 

Value

Unit

Value

Unit

Free VEGF concentration

Breast cancer

0.5–1.5

pM

2.6–7.83 10-4

pmol/cm3 tissue

Total tumor VEGF

Breast cancer

13

pg/mg tumor

0.3

pmol/cm3 tissue

VEGFR1 tissue concentration

 

102–105

#/EC

1.7 10-3–1.7 100

pmol/cm3 tissue

VEGFR2 tissue concentration

 

104

#/EC

1.7 10-1

pmol/cm3 tissue

NRP1 tissue concentration

 

103–106

#/EC

1.7 10-2-1.7 101

pmol/cm3 tissue

ECM binding site density

ECM

0.75

μ M

389

pmol/cm3 tissue

Vessel BM

13

μ M

4

pmol/cm3 tissue

Tumor cell BM

13

μ M

32

pmol/cm3 tissue

  1. The conversion of receptor densities to tissue concentrations is based on the relationship mentioned in table 5, and the surface area of an endothelial cell, 1000 μ m2. VEGF concentration is normalized based on the entire interstitial space, since it diffuses throughout: 5.2 108 (pmol/cm3 tissue)/M (here, M = moles/liter interstitial space). VEGF binding sites in the ECM and BMs are based on those volumes: 5.2 108 (pmol/cm3 tissue)/M(ECM), 2.7 105 (pmol/cm3 tissue)/M(EBM), 2.5 106 (pmol/cm3 tissue)/M(PBM) [4].