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Table 6 VEGF concentration and receptor densities for the tumor (breast cancer)

From: A compartment model of VEGF distribution in blood, healthy and diseased tissues

  Measured parameter Tissue model
  Value Unit Value Unit
Free VEGF concentration
Breast cancer 0.5–1.5 pM 2.6–7.83 10-4 pmol/cm3 tissue
Total tumor VEGF
Breast cancer 13 pg/mg tumor 0.3 pmol/cm3 tissue
VEGFR1 tissue concentration
  102–105 #/EC 1.7 10-3–1.7 100 pmol/cm3 tissue
VEGFR2 tissue concentration
  104 #/EC 1.7 10-1 pmol/cm3 tissue
NRP1 tissue concentration
  103–106 #/EC 1.7 10-2-1.7 101 pmol/cm3 tissue
ECM binding site density
ECM 0.75 μ M 389 pmol/cm3 tissue
Vessel BM 13 μ M 4 pmol/cm3 tissue
Tumor cell BM 13 μ M 32 pmol/cm3 tissue
  1. The conversion of receptor densities to tissue concentrations is based on the relationship mentioned in table 5, and the surface area of an endothelial cell, 1000 μ m2. VEGF concentration is normalized based on the entire interstitial space, since it diffuses throughout: 5.2 108 (pmol/cm3 tissue)/M (here, M = moles/liter interstitial space). VEGF binding sites in the ECM and BMs are based on those volumes: 5.2 108 (pmol/cm3 tissue)/M(ECM), 2.7 105 (pmol/cm3 tissue)/M(EBM), 2.5 106 (pmol/cm3 tissue)/M(PBM) [4].