Figure 1

The three basic scenarios that will be discussed in the following. Figure A depicts a receptor or scaffold protein with single protein ligands, i.e. each binding domain can recruit single proteins which do not possess further binding domains. A scaffold with multiprotein ligands is shown in Figure B. Some of the ligands are scaffolds themselves. The last scenario additionally includes receptor homodimerization. Heterodimerization on the other site corresponds to the scenario depicted in Figure B.