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Table 7 Reaction rules for the considered example of EGF and insulin receptor crosstalk.

From: Exact model reduction of combinatorial reaction networks

IR(0, 0, *, *) + Ins IR(I, 0, *, *) k1, k-1
IR(0, 0, *, *) + Ins IR(0, I, *, *) k1, k-1
IR(I, 0, *, *) + Ins IR(I, I, *, *) k2, k-2
IR(0, I, *, *) + Ins IR(I, I, *, *) k2, k-2
IR(0, 0, 0, *)    IR(0, 0, P, *) k3, k-3
IR(I, 0, 0, *)    IR(I, 0, P, *) k4, k-4
IR(0, I, 0, *)    IR(0, I, P, *) k4, k-4
IR(I, I, 0, *)    IR(I, I, P, *) k5, k-5
IR(*, *, P, *) + Shc(*) IR(*, *, Shc(*), *) k6, k-6
IR(I, I, Shc(0), *)    IR(I, I, Shc(P), *) k7, k-7
IR(*, *, Shc(P), *) + Grb 2(*) IR(*, *, Grb 2(*), *) k8, k-8
IR(*, *, Grb 2(0), *) + SOS(0) IR(*, *, SOS(0), *) k9, k-9
IR(*, *, Grb 2(0), *) + SOS(P) IR(*, *, SOS(P), *) k10, k-10
IR(*, *, SOS(0), *)    IR(*, *, SOS(P), *) k11, k-11
IR(0, 0, *, 0)    IR(0, 0, *, P) k12, k-12
IR(I, 0, *, 0)    IR(I, 0, *, P) k13, k-13
IR(0, I, *, 0)    IR(0, I, *, P) k13, k-13
IR(I, I, *, 0)    IR(I, I, *, P) k14, k-14
IR(*, *, *, P) + IRS(*) IR(*, *, *, IRS(*)) k15, k-15
IR(I, I, *, IRS(0))    IR(I, I, *, IRS(P)) k16, k-16
IR(*, *, *, IRS(P)) + Grb 2(*) IR(*, *, *, Grb 2(*)) k17, k-17
IR(*, *, *, Grb 2(0)) + SOS(0) IR(*, *, *, SOS(0)) k9, k-9
IR(*, *, *, Grb 2(0)) + SOS(P) IR(*, *, *, SOS(P)) k10, k-10
IR(*, *, *, SOS(0))    IR(*, *, *, SOS(P)) k11, k-11
Shc(0)    Shc(P) k18, k-18
Shc(P) + Grb 2(*) Shc(Grb 2(*)) k8, k-8
Shc(Grb 2(0)) + SOS(0) Shc(SOS(0)) k9, k-9
Shc(Grb 2(0)) + SOS(P) Shc(SOS(P)) k10, k-10
Shc(SOS(0))    Shc(SOS(P)) k11, k-11
Grb 2(0) + SOS(0) Grb 2(SOS(0)) k9, k-9
Grb 2(0) + SOS(P) Grb 2(SOS(P)) k10, k-10
Grb 2(SOS(0))    Grb 2(SOS(P)) k11, k-11
SOS(0)    SOS(P) k19, k-19
IRS(0)    IRS(P) k20, k-20
IRS(P) + Grb 2(*) IRS(Grb 2(*)) k17, k-17
IRS(Grb 2(0)) + SOS(0) IRS(SOS(0)) k9, k-9
IRS(Grb 2(0)) + SOS(P) IRS(SOS(P)) k10, k-10
IRS(SOS(0))    IRS(SOS(P)) k11, k-11
ER(0, *, *) + EGF ER(E, *, *) k21, k-21
ER(*, 0, *)    ER(*, P, *) k22, k-22
ER(*, P, *) + Shc(*) ER(*, Shc(*), *) k23, k-23
ER(*, Shc(0), *)    ER(*, Shc(P), *) k24, k-24
ER(*, Shc(P), *) + Grb 2(*) ER(*, Grb 2(*), *) k8, k-8
ER(*, Grb 2(0), *) + SOS(0) ER(*, SOS(0), *) k9, k-9
ER(*, Grb 2(0), *) + SOS(P) ER(*, SOS(P), *) k10, k-10
ER(*, SOS(0), *)    ER(*, SOS(P), *) k11, k-11
ER(*, *, 0)    ER(*, *, P) k25, k-25
ER(*, *, P) + Grb 2(*) ER(*, *, Grb 2(*)) k26, k-26
ER(*, *, Grb 2(0)) + SOS(0) ER(*, *, SOS(0)) k9, k-9
ER(*, *, Grb 2(0)) + SOS(P) ER(*, *, SOS(P)) k10, k-10
ER(*, *, SOS(0))    ER(*, *, SOS(P)) k11, k-11
ER(E, *, *) + ER(0, *, *) ER2(E, *, *, 0, *, *) k27, k-27
ER(0, *, *) + ER(0, *, *) ER2(0, *, *, 0, *, *) k28, k-28
ER(E, *, *) + ER(E, *, *) ER2(E, *, *, E, *, *) k29, k-29
ER2(0, *, *, *, *, *) + EGF ER2(E, *, *, *, *, *) k30, k-30
ER2(*, 0, *, *, *, *)    ER2(*, P, *, *, *, *) k31, k-31
ER2(*, Shc(0), *, *, *, *)    ER2(*, Shc(P), *, *, *, *) k32, k-32
ER2(*, P, *, *, *, *) + Shc(*) ER2(*, Shc(*), *, *, *, *) k23, k-23
ER2(*, Shc(P), *, *, *, *) + Grb 2(*) ER2(*, Grb 2(*), *, *, *, *) k8, k-8
ER2(*, Grb 2(0), *, *, *, *) + SOS(0) ER2(*, SOS(0), *, *, *, *) k9, k-9
ER2(*, Grb 2(0), *, *, *, *) + SOS(P) ER2(*, SOS(P), *, *, *, *) k10, k-10
ER2(*, SOS(0), *, *, *, *)    ER2(*, SOS(P), *, *, *, *) k11, k-11
ER2(*, *, 0, *, *, *)    ER2(*, *, 0, *, *, *) k33, k-33
ER2(*, *, P, *, *, *) + Grb 2(*) ER2(*, *, Grb 2(*), *, *, *) k34, k-34
ER2(*, *, Grb 2(0), *, *, *) + SOS(0) ER2(*, *, SOS(0), *, *, *) k9, k-9
ER2(*, *, Grb 2(0), *, *, *) + SOS(P) ER2(*, *, SOS(P), *, *, *) k10, k-10
ER2(*, SOS(0), *, *, *, *)    ER2(*, *, SOS(P), *, *, *) k11, k-11