Table 7 Reaction rules for the considered example of EGF and insulin receptor crosstalk.
From: Exact model reduction of combinatorial reaction networks
IR(0, 0, *, *) | + | Ins | ⇋ | IR(I, 0, *, *) | k1, k-1 |
IR(0, 0, *, *) | + | Ins | ⇋ | IR(0, I, *, *) | k1, k-1 |
IR(I, 0, *, *) | + | Ins | ⇋ | IR(I, I, *, *) | k2, k-2 |
IR(0, I, *, *) | + | Ins | ⇋ | IR(I, I, *, *) | k2, k-2 |
IR(0, 0, 0, *) | ⇋ | IR(0, 0, P, *) | k3, k-3 | ||
IR(I, 0, 0, *) | ⇋ | IR(I, 0, P, *) | k4, k-4 | ||
IR(0, I, 0, *) | ⇋ | IR(0, I, P, *) | k4, k-4 | ||
IR(I, I, 0, *) | ⇋ | IR(I, I, P, *) | k5, k-5 | ||
IR(*, *, P, *) | + | Shc(*) | ⇋ | IR(*, *, Shc(*), *) | k6, k-6 |
IR(I, I, Shc(0), *) | ⇋ | IR(I, I, Shc(P), *) | k7, k-7 | ||
IR(*, *, Shc(P), *) | + | Grb 2(*) | ⇋ | IR(*, *, Grb 2(*), *) | k8, k-8 |
IR(*, *, Grb 2(0), *) | + | SOS(0) | ⇋ | IR(*, *, SOS(0), *) | k9, k-9 |
IR(*, *, Grb 2(0), *) | + | SOS(P) | ⇋ | IR(*, *, SOS(P), *) | k10, k-10 |
IR(*, *, SOS(0), *) | ⇋ | IR(*, *, SOS(P), *) | k11, k-11 | ||
IR(0, 0, *, 0) | ⇋ | IR(0, 0, *, P) | k12, k-12 | ||
IR(I, 0, *, 0) | ⇋ | IR(I, 0, *, P) | k13, k-13 | ||
IR(0, I, *, 0) | ⇋ | IR(0, I, *, P) | k13, k-13 | ||
IR(I, I, *, 0) | ⇋ | IR(I, I, *, P) | k14, k-14 | ||
IR(*, *, *, P) | + | IRS(*) | ⇋ | IR(*, *, *, IRS(*)) | k15, k-15 |
IR(I, I, *, IRS(0)) | ⇋ | IR(I, I, *, IRS(P)) | k16, k-16 | ||
IR(*, *, *, IRS(P)) | + | Grb 2(*) | ⇋ | IR(*, *, *, Grb 2(*)) | k17, k-17 |
IR(*, *, *, Grb 2(0)) | + | SOS(0) | ⇋ | IR(*, *, *, SOS(0)) | k9, k-9 |
IR(*, *, *, Grb 2(0)) | + | SOS(P) | ⇋ | IR(*, *, *, SOS(P)) | k10, k-10 |
IR(*, *, *, SOS(0)) | ⇋ | IR(*, *, *, SOS(P)) | k11, k-11 | ||
Shc(0) | ⇋ | Shc(P) | k18, k-18 | ||
Shc(P) | + | Grb 2(*) | ⇋ | Shc(Grb 2(*)) | k8, k-8 |
Shc(Grb 2(0)) | + | SOS(0) | ⇋ | Shc(SOS(0)) | k9, k-9 |
Shc(Grb 2(0)) | + | SOS(P) | ⇋ | Shc(SOS(P)) | k10, k-10 |
Shc(SOS(0)) | ⇋ | Shc(SOS(P)) | k11, k-11 | ||
Grb 2(0) | + | SOS(0) | ⇋ | Grb 2(SOS(0)) | k9, k-9 |
Grb 2(0) | + | SOS(P) | ⇋ | Grb 2(SOS(P)) | k10, k-10 |
Grb 2(SOS(0)) | ⇋ | Grb 2(SOS(P)) | k11, k-11 | ||
SOS(0) | ⇋ | SOS(P) | k19, k-19 | ||
IRS(0) | ⇋ | IRS(P) | k20, k-20 | ||
IRS(P) | + | Grb 2(*) | ⇋ | IRS(Grb 2(*)) | k17, k-17 |
IRS(Grb 2(0)) | + | SOS(0) | ⇋ | IRS(SOS(0)) | k9, k-9 |
IRS(Grb 2(0)) | + | SOS(P) | ⇋ | IRS(SOS(P)) | k10, k-10 |
IRS(SOS(0)) | ⇋ | IRS(SOS(P)) | k11, k-11 | ||
ER(0, *, *) | + | EGF | ⇋ | ER(E, *, *) | k21, k-21 |
ER(*, 0, *) | ⇋ | ER(*, P, *) | k22, k-22 | ||
ER(*, P, *) | + | Shc(*) | ⇋ | ER(*, Shc(*), *) | k23, k-23 |
ER(*, Shc(0), *) | ⇋ | ER(*, Shc(P), *) | k24, k-24 | ||
ER(*, Shc(P), *) | + | Grb 2(*) | ⇋ | ER(*, Grb 2(*), *) | k8, k-8 |
ER(*, Grb 2(0), *) | + | SOS(0) | ⇋ | ER(*, SOS(0), *) | k9, k-9 |
ER(*, Grb 2(0), *) | + | SOS(P) | ⇋ | ER(*, SOS(P), *) | k10, k-10 |
ER(*, SOS(0), *) | ⇋ | ER(*, SOS(P), *) | k11, k-11 | ||
ER(*, *, 0) | ⇋ | ER(*, *, P) | k25, k-25 | ||
ER(*, *, P) | + | Grb 2(*) | ⇋ | ER(*, *, Grb 2(*)) | k26, k-26 |
ER(*, *, Grb 2(0)) | + | SOS(0) | ⇋ | ER(*, *, SOS(0)) | k9, k-9 |
ER(*, *, Grb 2(0)) | + | SOS(P) | ⇋ | ER(*, *, SOS(P)) | k10, k-10 |
ER(*, *, SOS(0)) | ⇋ | ER(*, *, SOS(P)) | k11, k-11 | ||
ER(E, *, *) | + | ER(0, *, *) | ⇋ | ER2(E, *, *, 0, *, *) | k27, k-27 |
ER(0, *, *) | + | ER(0, *, *) | ⇋ | ER2(0, *, *, 0, *, *) | k28, k-28 |
ER(E, *, *) | + | ER(E, *, *) | ⇋ | ER2(E, *, *, E, *, *) | k29, k-29 |
ER2(0, *, *, *, *, *) | + | EGF | ⇋ | ER2(E, *, *, *, *, *) | k30, k-30 |
ER2(*, 0, *, *, *, *) | ⇋ | ER2(*, P, *, *, *, *) | k31, k-31 | ||
ER2(*, Shc(0), *, *, *, *) | ⇋ | ER2(*, Shc(P), *, *, *, *) | k32, k-32 | ||
ER2(*, P, *, *, *, *) | + | Shc(*) | ⇋ | ER2(*, Shc(*), *, *, *, *) | k23, k-23 |
ER2(*, Shc(P), *, *, *, *) | + | Grb 2(*) | ⇋ | ER2(*, Grb 2(*), *, *, *, *) | k8, k-8 |
ER2(*, Grb 2(0), *, *, *, *) | + | SOS(0) | ⇋ | ER2(*, SOS(0), *, *, *, *) | k9, k-9 |
ER2(*, Grb 2(0), *, *, *, *) | + | SOS(P) | ⇋ | ER2(*, SOS(P), *, *, *, *) | k10, k-10 |
ER2(*, SOS(0), *, *, *, *) | ⇋ | ER2(*, SOS(P), *, *, *, *) | k11, k-11 | ||
ER2(*, *, 0, *, *, *) | ⇋ | ER2(*, *, 0, *, *, *) | k33, k-33 | ||
ER2(*, *, P, *, *, *) | + | Grb 2(*) | ⇋ | ER2(*, *, Grb 2(*), *, *, *) | k34, k-34 |
ER2(*, *, Grb 2(0), *, *, *) | + | SOS(0) | ⇋ | ER2(*, *, SOS(0), *, *, *) | k9, k-9 |
ER2(*, *, Grb 2(0), *, *, *) | + | SOS(P) | ⇋ | ER2(*, *, SOS(P), *, *, *) | k10, k-10 |
ER2(*, SOS(0), *, *, *, *) | ⇋ | ER2(*, *, SOS(P), *, *, *) | k11, k-11 |