(A) The phenotypic phase plane analysis showed growth rate as a function of OUR and TUR in i JN746. The growth rate is given in 1/h (color legend). The red and yellow lines represent OUR constrained to 20.93 and 33 mmol/gDW/h, respectively. (B) Diagram of oxygen producing and reducing reactions in i JN746. The flux rates are given in mmol/gDW/h and represent one possible flux state of the network in toluene minimal medium at an OUR of 40 mmol oxygen/gDW/h. The reaction abbreviations are as follows: CAT, catalase; O2tpp, oxygen periplasmic transport (oxygen uptake); ASPO6, L-aspartate oxidase; BZ12DOX, benzoate 1,2-dioxygenase; CAT23DOX, catechol 2,3-dioxygenase; CYTBO3_4pp, cytochrome oxidase bo3; DHORD, dihydoorotic acid dehydrogenase; GLYCTO1, Glycolate oxidase and XMO, toluene monooxygenase.