TY - JOUR AU - Cui, Jiangjun AU - Kaandorp, Jaap A. AU - Lloyd, Catherine M. PY - 2008 DA - 2008/10/24 TI - Simulating in vitro transcriptional response of zinc homeostasis system in Escherichia coli JO - BMC Systems Biology SP - 89 VL - 2 IS - 1 AB - The zinc homeostasis system in Escherichia coli is one of the most intensively studied prokaryotic zinc homeostasis systems. Its underlying regulatory machine consists of repression on zinc influx through ZnuABC by Zur (Z n2+ u ptake r egulator) and activation on zinc efflux via ZntA by ZntR (a zinc-responsive regulator). Although these transcriptional regulations seem to be well characterized, and there is an abundance of detailed in vitro experimental data available, as yet there is no mathematical model to help interpret these data. To our knowledge, the work described here is the first attempt to use a mathematical model to simulate these regulatory relations and to help explain the in vitro experimental data. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-2-89 DO - 10.1186/1752-0509-2-89 ID - Cui2008 ER -