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Figure 7 | BMC Systems Biology

Figure 7

From: Dynamics of receptor and protein transducer homodimerisation

Figure 7

Dynamic simulation. Dynamical simulation of the system when dual mechanism and asymmetric deactivation of the receptor are assumed. The dynamics of the protein was complemented with a rate describing de deactivation and break down of the homodimeric protein P*P* ( r P P deact MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaemOCai3aaSbaaSqaaiabdcfaqnaaCaaameqabaGaey4fIOcaaSGaemiuaa1aa0baaWqaaiabbsgaKjabbwgaLjabbggaHjabbogaJjabbsha0bqaaiabgEHiQaaaaSqabaaaaa@38B5@ = k4·P*P*). Figure 7 [a]: Time course for the relevant variables of the system: monomeric activated protein (P*), fully activated receptor (R*R*) and partially activated receptor (R*R). Figure 7 [b]: Time course for single (rSA) and double (rDA) protein activation rates during the simulation. Initial conditions: P(0) = 1.0; P*(0) = 0.0; R*R*(0) = 0:5; R*R(0) = 0.0. Parameter values: k1 = 0.02; k2 = 0 > 05; k3 = 5*k1 = 0.1; k4 = 0.0125; kD1 = kD2 = 0.01.

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