|
Category
|
Symbol
|
Reaction
|
Value (s-1)
|
Ref.
|
|---|
|
protein dimerization
|
k
1
|
P1 + P1 → P2
|
0.001–0.1
|
[51, 52]
|
| |
q
1
|
P2 → P1 + P1
|
0.1–1
| |
|
TF-operator int
|
k
20
|
P2 + D00 → D20
|
0.012
|
[53–55]
|
| |
q
20
|
D20 → P2 + D00
|
0.9
| |
| |
k
21
|
P1 + D00 → D10
|
0.038
| |
| |
q
21
|
D10 → P1 + D00
|
0.3
| |
| |
k
22
|
P1 + D10 → D20
|
0.011
| |
| |
q
22
|
D20 → P1 + D10
|
0.9
| |
|
RNAp-promoter int
|
k
30
|
R + D00 → D01
|
0.038
|
[56–58]
|
| |
q
30
|
D01 → R + D00
|
0.3
| |
| |
k
31
|
R + D10 → D11
|
0.038†, 0.38‡
| |
| |
q
31
|
D11 → R + D10
|
0.3†, 0.03‡
| |
| |
k
32
|
R + D20 → D21
|
0.38*†
| |
| |
q
32
|
D21 → R + D20
|
0.03*†
| |
|
Isomerization
|
ν
|
Dx1 → C + Dx0
|
0.0078
|
[55]
|
|
tsx-tsl elongation & decay
|
α
|
C → M + R
|
0.03
|
[59, 60]
|
| |
β
|
M → P1 + M
|
0.044
| |
| |
γ
0
| M → ∅ |
0.0039
| |
| |
γ
1
|
P1 → ∅ |
7 × 10-4
| |
| |
γ
2
|
P2 → ∅ |
0.7–3.5 × 10-4
| |
- Kinetic rates for the positive autogenous circuit. Experimentally available rates are all taken from lambda phage-E. coli complex. The values with superscript correspond to the circuit topologies DA1 (*), DA2 (†), and DA3 (‡) in Fig. 1.
