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Table 5 Pearson correlations (r) between the expression profiles of the 29 candidate genes from the standard analysis and MEblue, severity, and the TPH2 SNP.

From: Integrated Weighted Gene Co-expression Network Analysis with an Application to Chronic Fatigue Syndrome

  Candidate Genes from Standard Gene Name and Genbank Accession Pearson correlations with gene expression profiles
   MEblue CFS Severity TPH2 SNP
   r: All Rank1 r: All p-value r: M r: F r: All p-value r: M r: F
1 DGCR8 (AF165527) 0.81 329 0.37 <0.001 0.35 0.39 0.13 0.14 0.12 0.12
2 PPARD (BC002715) 0.54 2305 0.37 0.001 0.49 0.34 0.10 0.25 0.18 0.08
3 IHPK2 (BC004469) 0.48 2842 0.36 0.001 0.36 0.36 0.15 0.09 0.02 0.16
4 CCDC92 (AB015292) 0.43 3434 0.35 0.001 0.33 0.38 0.07 0.42 -0.07 0.10
5 NR5A2 (AB019246) 0.47 2945 0.35 0.001 0.37 0.32 0.10 0.27 0.18 0.07
6 PDPK1 (BC006339) 0.67 1218 0.35 0.001 0.47 0.31 0.16 0.08 0.24 0.12
7 NXF1 (AF112880) 0.63 1517 0.34 0.001 0.17 0.36 0.15 0.10 -0.03 0.15
8 COL13A1 (NM_080804) 0.51 2590 0.34 0.001 0.25 0.34 0.05 0.60 -0.10 0.06
9 AXIN2 (AF078165) 0.80 414 0.33 0.002 0.39 0.32 0.13 0.15 0.16 0.10
10 SCAP (AK075528) 0.64 1458 0.33 0.002 0.44 0.36 0.17 0.06 0.38 0.12
11 DFFA (AF087573) 0.71 948 0.33 0.002 0.25 0.35 0.11 0.21 0.07 0.10
12 TCF4 (M74719) 0.76 637 0.33 0.002 0.38 0.31 0.14 0.13 0.15 0.11
13 WNT16 (NM_016087) 0.71 910 0.33 0.002 0.38 0.32 0.08 0.36 0.13 0.05
14 ZNF687 (BC032463) 0.83 243 0.33 0.002 0.53 0.30 0.10 0.28 0.29 0.04
15 FGF1 (BC032697) 0.65 1378 0.32 0.003 0.26 0.31 0.02 0.83 -0.03 0.00
16 ANKRD6 (BC001078) 0.83 241 0.31 0.003 0.36 0.28 0.14 0.12 0.23 0.09
17 EPHX1 (M36374) 0.64 1442 0.31 0.003 0.24 0.33 0.11 0.22 -0.01 0.12
18 FAIM (AK001444) 0.86 132 0.31 0.004 0.34 0.30 0.07 0.43 0.11 0.04
19 ZMYND11 (NM_006624) 0.67 1223 0.31 0.004 0.47 0.26 0.13 0.15 0.32 0.07
20 ADFP (NM_001122) 0.69 1057 0.31 0.004 0.27 0.32 0.11 0.20 0.12 0.10
21 BAT5 (BC031839) 0.73 802 0.31 0.004 0.27 0.31 0.10 0.24 0.08 0.09
22 CEBPA (NM_004364) 0.70 980 0.31 0.004 0.16 0.32 0.08 0.38 -0.16 0.10
23 HNRNPA1 (NM_002136) 0.46 3048 0.30 0.004 0.23 0.34 0.11 0.23 -0.12 0.15
24 DMBT1 (NM_004406) 0.59 1874 0.30 0.005 0.50 0.24 0.08 0.37 0.20 0.03
25 RNASEN (AF116910) 0.75 680 0.30 0.005 0.29 0.31 0.10 0.26 0.09 0.08
26 EDAR (AF130988) 0.82 288 0.30 0.005 0.20 0.33 0.09 0.32 -0.02 0.09
27 F3 (AF540377) 0.67 1181 0.30 0.005 0.28 0.30 0.10 0.26 0.18 0.06
28 HSPG2 (AL445795) 0.30 4880 0.30 0.005 0.09 0.33 -0.03 0.71 -0.25 -0.02
29 EIF2C2 (AF121255) 0.60 1760 0.30 0.005 0.29 0.27 0.18 0.04 0.27 0.13
  Median2: 0.67 1218 0.32 0.003 0.33 0.32 0.10 0.24 0.13 0.09
  1. The correlations were computed using the 127 samples studied (All), the 98 female samples and the 29 male samples except for the correlation with severity which only had 87 non-missing scores (64 female and 23 male). Four of the candidate genes indicated in bold satisfied our IWGCNA screening criteria (excluding blue module membership). The CFS Severity column is bolded forclarity.
  2. 1The rank of each gene in terms of its MEblue correlation out of the 8966 genes used to start the analysis.
  3. 2The median was computed using the absolute value.