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Figure 6 | BMC Systems Biology

Figure 6

From: Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway

Figure 6

Simulation results from EGFR mutation model: All the lines in these graphs represent simulated active ERK levels over 600 minutes. (A) Ras and Raf-1 Knockouts: The blue line represents active ERK levels with an EGFR mutation, whereas, the red and green lines represent active ERK levels with an EGFR mutation but also with a Ras or Raf-1 knockout, respectively; the green line is practically identical to the blue line and hence obscures the blue line from view. (B) Rap1 and B-Raf Knockouts: The blue line is the same as in (A), whereas, the red and green lines represent active ERK levels with an EGFR mutation but also with a Rap1 or B-Raf knockout, respectively.

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