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Figure 7 | BMC Systems Biology

Figure 7

From: Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway

Figure 7

Experimental results of Rap1 pathway knockout from Falco et al. (2007) [37]: On the left, is a schematic of the mutated RET/PTC1 pathway as presented in [37]. On the right, is a table containing a summary of the results from the Gab1 knock down experiment using si-RNA in two different human PTC cell lines (BHP 10-3 and BHP 2-7) from [37] (please refer to Figure 5c in [37] for original blots); pMEK and pERK represent the activated phosphorylated forms of MEK and ERK, respectively, whilst Rap1GTP represents the activated GTP loaded form of Rap1.

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