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Table 1 Maximum Percentage error in reaction velocity from prediction of the MM equation for Model I.

From: Investigating the robustness of the classical enzyme kinetic equations in small intracellular compartments

D/nm

K M = 10 μM

100 μM

1000 μM

Copy No.

50

11.83 [17.00]

4.09 [4.33]

0.59

10

100

4.74 [5.00]

0.73 [0.74]

0.08

10

200

0.90

0.10

0.01

10

50

3.98 [5.33]

1.88 [2.02]

0.43

100

100

2.10 [2.23]

0.52 [0.52]

0.07

100

200

0.61

0.09

0.01

100

  1. The copy number indicates the total number of enzyme molecules per compartment. Values in bold and in square brackets are those estimated by simulation; the italic values are obtained from the derived theoretical expressions, Eqs. (7) and (8).
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BMC Systems Biology

ISSN: 1752-0509

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