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Table 2 Maximum Percentage error in reaction velocity from prediction of the MM equation for Model II.

From: Investigating the robustness of the classical enzyme kinetic equations in small intracellular compartments

D/nm

K M = 10 μM

100 μM

1000 μM

Copy No.

50

225.40

152.83 [291.56]

45.43

10

100

161.59 [331.66]

52.74 [58.39]

6.82 [6.99]

10

200

65.09

8.45 [8.50]

0.88

10

50

32.97

30.17 [61.66]

18.14

100

100

30.78 [66.03]

19.76 [24.52]

5.57 [6.06]

100

200

21.27

6.61 [6.91]

0.85

100

  1. The copy number indicates the total number of enzyme molecules per compartment. Values in bold and in square brackets are those estimated by simulation; the italic values are obtained from the theoretical expressions, Eqs. (7) and (9).