Submodel | Variables | Interpetation | Dim. | Eqn. | Param. | timescale |
---|---|---|---|---|---|---|
Protein | a a | Free amino acids (AA) concentration | â„™20 | Table 2 | Table 3 | medium |
a p | Amino acids channeled to protein synthesis | â„™20 | medium | |||
a b | Amino acids channeled to catabolism (break-down) | â„™20 | medium | |||
p a | Tissue protein, given by its amino acids composition | â„™20 | slow | |||
Lipid | AcCoA cyt | Acetyl-CoA in the cytosol | â„™1 | Table 4 | Table 5 | fast |
malCoA | Malonyl-CoA | â„™1 | fast | |||
FA | Fatty acids (palmitate) | â„™1 | medium | |||
TAG | Tri-acylglycerol | â„™1 | slow | |||
Intermediate metabolism | pyr | Pyruvate | â„™1 | Table | Table 8 | fast |
6, 7 | ||||||
AcCoA | Acetyl-Coa (matrix) | â„™1 | fast | |||
cit | Citrate concentrations in the mitochondria | â„™1 | fast | |||
iso | Isocitrate concentrations in the mitochondria | â„™1 | fast | |||
keto | α-ketoglutrate concentrations in the mitochondria | ℙ1 | fast | |||
succ | Succinate concentrations in the mitochondria | â„™1 | fast | |||
mal | Malate concentrations in the mitochondria | R1 | fast | |||
oxal | Oxaloacetate concentrations in the mitochondria | â„™1 | fast | |||
mal cyt | Malate concentrations in the cytosol | â„™1 | fast | |||
oxal cyt | Oxaloacetate concentrations in the cytosol | â„™1 | fast | |||
Glu | Glucose concentrations (glycolysis process) | â„™1 | Table 9 | Table 9 | fast | |
g6p | glucose-6-phosphate concentrations (glycolysis) | â„™1 | fast | |||
pGt | 6-phosphogluconate concentrations (glycolysis) | â„™1 | fast | |||
G3p | glyceraldehyde 3-phospate concentrations (glycolysis) | â„™1 | fast | |||
(feed) | u feed | The nutrients FA, glucose and 20 amino acids consumed | â„™23 | N/A | N/A | medium |
Output | y(t) | The output of the model, consists of protein (sum of its amino acids), storage lipids (TAG), NH3, O2 and CO2, all in units of gram | â„™5 | N/A | N/A | f/s/m |