Table 5 Lipid metabolism - parameters.

k_{q 1}, k _ls , k _ld

rate constants for the lipid metabolism reactions

1, 1, 0.1/μ mol/s

assumed

k_{q 2}, k _xd

rate constants for the lipid metabolism reactions

100, 0.3/μ mol²/s

assumed

V _fs

maximal velocity of FA synthesis, estimated to produce rapid Hill reaction, according to [45]

60

estimated

β _fs

Hill coefficient FA synthesis

3

[45]

citrate concentration at half FA synthesis reaction

0.2 μ mol/g

[45]

capacity of TAG deposition in the body

30%

[63]

β _ls

exponential coefficient for TAG deposition, estimated from simulations producing slow Hill dynamics

2

estimated

V _ls

gain of the lipid synthesis function, estimated from simulation

1μ mol

estimated

β _xd

Hill coefficient of the β-oxidation process

4

assumed

concentration of ATP at half saturation of β-oxidation process

7 μ mol/g

[25, 64, 65]

V _xd

maximal velocity of β-oxidation

0.3 μ mol

[53]

β _ld

Hill coefficient of TAG degradation. Estimated from [25, 66] and simulations to maintain reasonable Hill dynamics

4

estimated

concentrations of ATP at half saturation in the TAG degradation process

7.8μ mol/g

[25, 66]

V _ld

maximal velocity TAG degradation. Estimated from [25, 66] and simulations to maintain reasonable Hill dynamics

10μ mol

estimated