Figure 5

Approaches for visualizing molecular interaction networks. A) Protein network involving 22 established human TS and their interacting partners as found in PFAM DAS service [24], summing up 590 nodes and 771 edges (fragment is shown). TS are depicted in boxes, while other proteins are ellipses in the graph. Edges represent domain-domain interactions between two TS proteins, or most commonly between a TS and a non-TS protein. See tumorSuppressorNetwork_Fig5AB.m to run the example. B) Subgraph showing common domain-domain interactions for p53 and Brca1. C) Heatmap visualization of an integrated TS network created by fetching data from 11 DAS sources using DASMiner. D) Zooming in a group of 30 proteins in the heatmap. See createTSConnectionHeatmap_Fig5CD.m for a complete list of accessed DAS sources and to reproduce heatmaps C and D.