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Figure 1 | BMC Systems Biology

Figure 1

From: A Drosophila systems model of pentylenetetrazole induced locomotor plasticity responsive to antiepileptic drugs

Figure 1

Chronic PTZ and subsequent withdrawal induced climbing abnormalities. Mean + S. E. (n = 24) of climbing speed in flies used for control experiments and for simulating PTZ induced kindling-like plasticity. In control experiments, five batches of flies were treated with NF for either 7 days (A) or 14 days (B) before measuring climbing speed. In chronic PTZ experiment (C), climbing speed was measured on 12 hrs, 2nd day and 7th day of PTZ treatment and then on 3rd day, 5th day, and 7th day after PTZ withdrawal. For control climbing assay to examine consistency among NF flies housed in different vials (A and B), one-way ANOVA as well as pair-wise Student's t-test, two-tailed, heteroscedastic, uncorrected, was performed. After finding no significant variation by either method, Student's t-test was performed as above for chronic PTZ experiment (C). * indicates significant difference between control (NF) and PTZ treatment. p values (pair-wise Student's t-test, two-tailed) are provided over asterisks. For details, see text.

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