Figure 3
Which measure of closeness best correlates with functional distance? The average functional distance of pairs in the top percentile of each closeness ranking is displayed. Lower values indicate measures that are more biologically meaningful. (a) The results for the AC-Western network. (b) The results for the AC-MS network. (c) The results for the Two-Hybrid network. The average functional distance of two proteins in the genome is 5.8.