TY - JOUR AU - Sprinzak, Einat AU - Cokus, Shawn J. AU - Yeates, Todd O. AU - Eisenberg, David AU - Pellegrini, Matteo PY - 2009 DA - 2009/12/14 TI - Detecting coordinated regulation of multi-protein complexes using logic analysis of gene expression JO - BMC Systems Biology SP - 115 VL - 3 IS - 1 AB - Many of the functional units in cells are multi-protein complexes such as RNA polymerase, the ribosome, and the proteasome. For such units to work together, one might expect a high level of regulation to enable co-appearance or repression of sets of complexes at the required time. However, this type of coordinated regulation between whole complexes is difficult to detect by existing methods for analyzing mRNA co-expression. We propose a new methodology that is able to detect such higher order relationships. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-3-115 DO - 10.1186/1752-0509-3-115 ID - Sprinzak2009 ER -