Gene-node convention for the iHSLN construction. Every node in yeast SL network (YSLN) has associated gene. (A) For n-to-one, the corresponding node in the iHSLN contains the human paralogs of the yeast homologous counterpart. (B) In the case that two SL yeast partners are phylogenetically related to a single human gene, an autolink appears in the human SL network. This is and artifact of the method. However, we have kept this information to provide a more detailed picture in case such a node is a suitable candidate.