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Table 3 A selection of cancer-unrelated SL partners of cancer-related genes and their associated drugs.

From: Human synthetic lethal inference as potential anti-cancer target gene detection

Drug-target name Drug (Description)
CDC25B Beta-Mercaptoethanol (Glutathione S-Transferase inhibitor); Cysteinesulfonic Acid(Peroxiredoxin inhibitor); Double Oxidized Cysteine (Peptide Deformylase Pdf1 inhibitor)
CDC42 Aminophosphonic Acid-Guanylate Ester (G25K GTP-Binding Protein inhibitor)
CDK2 4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine (Cell Division Protein Kinase 2 inhibitor)
DDX6 D-tartaric acid (D-tartaric acid)
EIF4E 7-Methyl-Gpppa (Eukaryotic Translation Initiation Factor 4E inhibitor); 7n- Methyl-8-Hydroguanosine-5'-Diphosphate (Vp39 inhibitor)
GDI1 Geran-8-Yl Geran(Rab GDP Disossociation Inhibitor Alpha inhibitor)
GRB2 4- [(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo- 7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid (Growth Factor Receptor-Bound Protein 2 inhibitor)
HSP90AB1 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine (Heat Shock Protein Hsp 90-Beta inhibitor)
HSPA5 antihemophilic factor (Coagulation factor VIII precursor)
LSS Dihydrofolic Acid (Dihydrofolate Reductase inhibitor)
PPP1CC 9,10-Deepithio-9,10-Didehydroacanthifolicin (Serine/Threonine Protein Phos phatase Pp1-Gam inhibitor)
PPP2CA Vitamin E (Dietary supplement)
PPP3R2 Cyclosporine (Investigational Immunomodulatory Agents; Immunosuppressive Agents; Antifungal Agents; Dermatologic Agents; Enzyme Inhibitors; An tirheumatic Agents For treatment of transplant rejection, rheumatoid arthritis, severe psoriasis)
PRDX2 3-Sulfinoalanine (3-Hydroxy-3-Methylglutaryl-Coa Synthase inhibitor)
SEC14L2 Palmitic Acid (Enzyme Inhibitors)
SNAP25 Botulinum Toxin Type A (Anti-Wrinkle Agents; Antidystonic Agents; Neuromuscular Blocking Agents)
SOD1 S-Oxy Cysteine (Prolyl Oligopeptidase inhibitor)
SQLE Naftifine (Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents)
  1. These drugs are not oriented to anti-cancer treatment. In this list we excluded general metabolites described as dietary supplements in DrugBank. A short description of drug activities are provided in parenthesis.