Figure 2
From: Flux-sum analysis: a metabolite-centric approach for understanding the metabolic network
Basal flux-sum vs degree of participation. Most of the 17 metabolic cofactors with high flux-sum were highly connected and participated in proportionally as many basal active reactions, except for periplasmic hydrogen ions (red marker). The R-square value for the linear relationship was 0.912 without considering the outlier (red marker). The 17 metabolites are ADP [c], ATP [c], CO2 [c], H2O [c], H+ [c], NAD [c], NADH [c], PI [c], Q8 [c], Q8H2 [c], CO2 [p], H2O [p], H+ [p], O2 [p], CO2 [e], H2O [e] and O2 [e]. Only ADP [c], ATP [c], H2O [c], H+ [c], H+ [p] and PI [c] have ultra-high flux-sum.