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Table 1 ISEA CELL axioms

From: A computational approach to resolve cell level contributions to early glandular epithelial cancer progression

Axiom Precondition* Action References
1 CELLS only DIE and leave behind a LUMINAL SPACE [3, 5, 51, 52]
2 LUMINAL SPACE only DIE and leave behind a LUMINAL SPACE [3, 5, 51, 52]
3 MATRIX only DIVIDE; the daughter CELL replaces a randomly selected MATRIX [3, 22, 53]
4 1 CELL and LUMINAL SPACES; no MATRIX Produce and deposit MATRIX between self and the adjoining CELL [21, 54]
5 ≥2 CELLS and LUMINAL SPACE; no MATRIX DIE and leave behind a LUMINAL SPACE [19, 20, 51]
6 ≥1 CELL and MATRIX; no LUMINAL SPACE DIVIDE; the daughter CELL replaces MATRIX that maximizes its number of CELL neighbors [23, 53, 54]
7 MATRIX and ≥2 LUMINAL SPACES; no CELLS DIVIDE; the daughter CELL replaces LUMINAL SPACE that adjoins MATRIX [2, 23]
8 CELLS, MATRIX, and ≥2 adjacent LUMINAL SPACES DIVIDE; the daughter CELL replaces LUMINAL SPACE that adjoins MATRIX and LUMINAL SPACE [2, 23]
9 2 CELLS, MATRIX, and LUMINAL SPACE; POLARIZING condition POLARIZE [2, 5]
10 DEPOLARIZING condition DEPOLARIZE [2, 5]
11 All other configurations Do nothing [2]
12 POLARIZING condition; 1 MATRIX Move and replace the neighboring MATRIX; leave behind a LUMINAL SPACE [2, 5]
  1. * The precondition for each axiomatic operating principle (Fig. 1) takes into consideration the six objects adjacent to the decision-making CELL. Two CELL neighbors separate MATRIX on one side from LUMINAL SPACE on the other side. A POLARIZED CELL has noncontiguous MATRIX neighbors.