A computational approach to resolve cell level contributions to early glandular epithelial cancer progression

BMC Systems Biology

Table 1 ISEA CELL axioms

Axiom	Precondition*	Action	References
1	CELLS only	DIE and leave behind a LUMINAL SPACE	[3, 5, 51, 52]
2	LUMINAL SPACE only	DIE and leave behind a LUMINAL SPACE	[3, 5, 51, 52]
3	MATRIX only	DIVIDE; the daughter CELL replaces a randomly selected MATRIX	[3, 22, 53]
4	1 CELL and LUMINAL SPACES; no MATRIX	Produce and deposit MATRIX between self and the adjoining CELL	[21, 54]
5	≥2 CELLS and LUMINAL SPACE; no MATRIX	DIE and leave behind a LUMINAL SPACE	[19, 20, 51]
6	≥1 CELL and MATRIX; no LUMINAL SPACE	DIVIDE; the daughter CELL replaces MATRIX that maximizes its number of CELL neighbors	[23, 53, 54]
7	MATRIX and ≥2 LUMINAL SPACES; no CELLS	DIVIDE; the daughter CELL replaces LUMINAL SPACE that adjoins MATRIX	[2, 23]
8	CELLS, MATRIX, and ≥2 adjacent LUMINAL SPACES	DIVIDE; the daughter CELL replaces LUMINAL SPACE that adjoins MATRIX and LUMINAL SPACE	[2, 23]
9	2 CELLS, MATRIX, and LUMINAL SPACE; POLARIZING condition^†	POLARIZE	[2, 5]
10	DEPOLARIZING condition^‡	DEPOLARIZE	[2, 5]
11	All other configurations	Do nothing	[2]
12	POLARIZING condition; 1 MATRIX	Move and replace the neighboring MATRIX; leave behind a LUMINAL SPACE	[2, 5]

* The precondition for each axiomatic operating principle (Fig. 1) takes into consideration the six objects adjacent to the decision-making CELL. ^† Two CELL neighbors separate MATRIX on one side from LUMINAL SPACE on the other side. ^‡ A POLARIZED CELL has noncontiguous MATRIX neighbors.

ISSN: 1752-0509