Figure 8
Effect of haploinsufficiency of Dll4 on blood vessel sprouting compared to control conditions. (A) Combined effect of [VEGF] and Dll4 haploinsufficiency (Dll4+/-) on total vessel growth after 24 hours. (B) Number of sprout tips as a function of [VEGF] and Dll4 haploinsufficiency after 24 hours. For (B), [VEGF] represents both the initial [VEGF], and the [VEGF] used in migration and proliferation rates. Gridspace volume is 1.28 × 106 μm3; initial tips were counted after two hours of stimuli. (C) and (D) Visual snapshots of the model output for control conditions (C) and Dll4+/- (D) after 24, 40 and 200 hrs, with a mean local VEGF concentration above the activation threshold of 0.5 ng/ml. The 24 and 40 hrs runs are in 3D, while the 200 hrs run is shown in 2D.