Figure 1

Schematic representation of the up and down-regulated genes in the central carbon metabolism following SDH3 deletion. Up-regulated genes are placed in black boxes, and down-regulated genes are placed in grey boxes. Thick arrows: drain of metabolites towards biomass production. Metabolites nomenclature: ACCOA, acetyl coenzyme A; ACA, acetaldehyde; ACE, acetate; AKG, 2-oxoglutarate; CIT, citrate; DHAP, dihydroxyacetone phosphate; ETH, ethanol; F6P, D-Fructose 6-phosphate; F16P D-Fructose 1,6-bisphosphate, FUM fumarate, GAP D-Glyceraldehyde 3-phosphate, G3P, Glycerol 3-phosphate; G6P, D-Glucose 6-phosphate; G15L, D-Glucono-1,5-lactone 6-phosphate; GLY, Glycerol; GLOX, Glyoxylate; GLC, Glucose; ICI, Isocitrate; MAL, Malate; OAA, Oxaloacetate; P13G, 3-Phospho-D-glyceroyl phosphate; P2G, 2-Phospho-D-glycerate; P3G, 3-Phospho-D-glycerate; P6G, 6-Phospho-D-gluconate; PEP, Phosphoenolpyruvate; PYR, pyruvate; RU5P, D-Ribulose 5-phosphate; SUC, Succinate; SUCCOA, Succinyl CoA.