Figure 2

Proposed regulatory model of the effects of SDH3 deletion. The model indicates a regulatory link that connects the respiratory dysfunction resulting from SDH3 deletion to changes in fatty acid metabolism and other pathways. Deletion of SDH3 leads to no/low respiration which is hypothesized to trigger regulatory circuits involving Hap2/3/4/5 complex, Hap1 and Ino4. Links that we could not find any data/literature evidences about are denoted by broken lines. Underlined gene names indicate down-regulation, while * denotes the genes/pathways for which similar changes in expression have been observed under anaerobic conditions for the reference strain.