Figure 2

Gene expression program emerging from the YMC. (a): The periodic genes of the YMC are grouped according to KEGG pathways (see Fig. S2 in Additional file 1) and then in the 15 macrocategories shown. For each macrocategory we calculate the average phase, HL, pulse width, and correlation of the periodic genes (in blue), and also the average HL and correlation of all genes (in red). Sorting by phase reveals the expected concatenation of events of the yeast gene expression program, especially in the first part with transcription preceding protein synthesis and DNA replication, followed by the slower categories of central metabolism. (b): Comparing HL and phase (or pulse width) roughly the same type of direct proportionality still appear. The trend in the average profiles of each category (black thick lines in (c)) reflects to a large extent that of Fig. 1. The third plot in (b) shows that also phase and pulse width are directly correlated: pulses that are delayed are also broadened. Linear regression for these plots is discussed in Additional file 1.