The manifestation of an allergic inflammation is significantly reduced in mice lacking ITK. Numbers of PAS-positive bronchial goblet cells (A). EPO-histochemistry was used to quantify the tissue eosinophilia in the upper airways, bronchi, and around large pulmonary vessels (B). Data are presented as means ± SEM. Stars denote levels of statistical difference between OVA-treated wild-type and ITK-deficient animals (* = P < 0.05, ** = P < 0.01, *** = P < 0.001).