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Table 4 Ratios of simulated acyl-CoA concentrations before and after fasting

From: Dynamic simulations on the mitochondrial fatty acid Beta-oxidation network

 

20%

30%

40%

Control C8-ratio

1.10

1.15

1.19

SCADD C4-ratio

1.28

1.44

1.62

MCADD C8-ratio

2.08

3.59

6.97

LCADD C14-ratio

2.29

2.89

3.46

VLCADD C14-ratio

1.16

1.25

1.33

  1. Ratios of simulated acyl-CoA concentrations before and 30 days after 20%, 30%, and 40% increase of palmitoyl-CoA (C16). Note that the time to attain the steady-state increases with higher increase of C16 and is in case of LCADD higher than 30 days for 30% and 40% increase of C16 resulting in lower ratios (2.89 and 3.46) than the ratios calculated for MCADD (3.59 and 6.97).
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BMC Systems Biology

ISSN: 1752-0509

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