Figure 6

Comparison of the simulated depolarization signals between single- and multiple-PDE1C models. Simulation results of single- and multiple-PDE1C models are shown in the left and right panels, respectively. The x-axis indicates the simulation time scale, and the y-axis indicates the intensity of depolarization of the olfactory receptor neutron. The values of "threshold" indicate the firing threshold of PDE1C in terms of their activity levels (see Figure 5C) set in the respective simulations. Depolarization signals were obtained using 50 replications of the respective simulation. (A) Results under the single-PDE1C model in which the firing threshold of PDE1C was set to 0 (threshold = 0). (B) Results under the multiple-PDE1C model (threshold = 0). (C) Results under the single-PDE1C model (threshold = 1). (D) Results under the multiple-PDE1C model (threshold = 1). (E) Results under the model of single-PDE1C (threshold = 1) and limited Ca²⁺ availability. (F) Results under the model of multiple-PDE1C (threshold = 1) and limited Ca²⁺ availability. (G) Results under the model of single-PDE1C (threshold = 1) and positive feedback circuit knocked out. (H) Results under the model of multiple-PDE1C (threshold = 1) and positive feedback circuit knocked out.