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Figure 5 | BMC Systems Biology

Figure 5

From: A framework for evolutionary systems biology

Figure 5

Canalisation and capacitance measure robustness. Let's assume a low-level property such as the kinetic rate of an enzyme has a certain distribution of mutational effects (black line) and influences a high-level property such as a fitness correlate (filled area). If the variance of the high-level property is smaller than that of the low-level property, then the high-level property can be said to experience 'canalisation'. Conversely, the high-level property experiences 'capacitance' if its variance is larger. To make these two properties comparable, their values on the x-axis are both plotted as relative deviations [(x mutant - x wild )/x wild ].

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